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Dermatologic Differential Diagnosis.pdf. - Famona Site

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lipoatrophic streaks extend down legs; high nasal bridge,<br />

prominent jaw, large ears, fat over suprapubic area and labia<br />

majora, fat pads over buttocks; hypotonia Textbook of Neonatal<br />

Dermatology, p.432, 2001<br />

Circumareolar telangiectasia AD 126:1656, 1990<br />

Galactorrhea of newborn – witches’ milk<br />

Mamillary fistula<br />

Pearls (milia) in newborn of areolae, scrotum, and labia majora<br />

of newborn Rook p.452, 1998, Sixth Edition<br />

Rudimentary nipples Humangenetik 15:268–269, 1972<br />

Supernumery nipples (accessory nipple or nipple nevus)<br />

Textbook of Neonatal Dermatology, p.118, 2001; Cutis<br />

62:235–237, 1998<br />

DRUG-INDUCED<br />

Diethylstilbestrol – florid papillomatosis after diethylstilbestrol<br />

therapy in males<br />

Nipple priapism JAMA 258:3122, 1987<br />

EXOGENOUS AGENTS<br />

Nipple rings Rook p.3158, 1998, Sixth Edition<br />

INFECTIONS AND INFESTATIONS<br />

Candida albicans – lactation Aust NZ J Obstet Gynaecol<br />

31:378–380, 1991<br />

Herpes simplex Tyring p.83, 2002<br />

Lyme disease (Borrelia burgdorferi) – lymphocytoma cutis;<br />

bluish–red plaque of nipple or areola JAAD 49:363–392, 2003;<br />

JAAD 47:530–534, 2002; Cutis 66:243–246, 2000; JAAD<br />

38:877–905, 1998<br />

Molluscum contagiosum<br />

Mycobacterium abscessus – subareolar abscess due to nipple<br />

piercing Clin Inf Dis 33:131–134, 2001<br />

Mycobacterium tuberculosis – lupus vulgaris Cutis 53:246–248,<br />

1994<br />

Scabies Rook p.1460–1461, 1998, Sixth Edition<br />

Syphilis – primary chancre; secondary Rook p.1244, 1998,<br />

Sixth Edition<br />

INFILTRATIVE LESIONS<br />

Mucinosis of the areolae – manifestation of CTCL<br />

Clin Exp Dermatol 21:374–376, 1996<br />

INFLAMMATORY LESIONS<br />

Lactation mastitis JAMA 289:1609–1612, 2003<br />

METABOLIC DISEASES<br />

Addison’s disease – hyperpigmentation of nipples Rook p.1779,<br />

1998, Sixth Edition<br />

Androgen excess – hyperpigmentation of areolae, axillae,<br />

external genitalia, perineum Ghatan p.165, 2002, Second<br />

Edition<br />

Nipple retraction of menopause Br Med J 309:797–800, 1994<br />

Pregnancy – hyperpigmentation of nipples Rook p.1780,3149,<br />

1998, Sixth Edition<br />

NIPPLE LESIONS, INCLUDING NIPPLE WITH MULTIPLE PAPULES 365<br />

NEOPLASTIC DISEASES<br />

Basal cell carcinoma – red plaque Derm Surg 27:971–974,<br />

2001; Cutis 54:85–92, 1994; including pigmented basal cell<br />

carcinoma (black nipple) AD 125:536–539, 1989<br />

Blue nevus<br />

Breast cancer – female or male; puckered nipple<br />

Carcinoma of the breast (primary), metastatic to nipple –<br />

cellulitis-like appearance of primary inflammatory breast<br />

carcinoma JAAD 43:733–751, 2000; female or male breast<br />

carcinoma – puckered nipple<br />

Dermatofibroma – atypical polypoid dermatofibroma<br />

JAAD 24:561–565, 1991<br />

Epidermal nevus Paris Med 28:63–66, 1938<br />

Epidermoid cyst<br />

Fox–Fordyce disease Rook p.3162, 1998, Sixth Edition<br />

Granular cell myoblastoma – nipple-like lesion AD<br />

121:927–932, 1985<br />

Hidradenoma papilliferum Hautarzt 19:101–109, 1968<br />

Hidradenoma<br />

Leiomyomas AD 127:571–576, 1991<br />

Leiomyosarcoma – blue–black; also red, brown, yellow or<br />

hypopigmented JAAD 46:477–490, 2002<br />

Lymphoma – cutaneous T-cell lymphoma mimicking<br />

hyperkeratosis of the nipple (hyperkeratosis areolae mammae)<br />

JAAD 41:274–276, 1999<br />

Lymphocytoma cutis<br />

Melanoma – primary, metastatic, amelanotic<br />

Milium<br />

Neurofibromas Rook p.3162, 1998, Sixth Edition<br />

Nevi, melanocytic<br />

Nevoid hyperkeratosis of the nipple JAAD 46:414–418, 2002;<br />

BJD 142:382–384, 2000; JAAD 41:325–326, 1999<br />

Paget’s disease of the breast (nipple) Rook p.1677–1678,2709,<br />

1998, Sixth Edition; <strong>Dermatologic</strong>a 170:170–179, 1985;<br />

Surg Gynecol Obstet 123:1010–1014, 1966<br />

Prostatic carcinoma metastases JAAD 18:391–393, 1988<br />

Sebaceous hyperplasia of areola JAAD 13:867–868, 1985<br />

Seborrheic keratoses Rook p.3161, 1998, Sixth Edition<br />

Steatocystoma multiplex<br />

Syringocystadenoma papilliferum<br />

Syringomas<br />

Syringomatous adenomas of the nipple<br />

NORMAL<br />

Montgomery’s tubercles JAAD 10:929–940, 1984; BJD<br />

86:126–133, 1972<br />

PRIMARY CUTANEOUS DISEASES<br />

Acanthosis nigricans JAAD 52:529–530, 2005; JAAD 31:1–19,<br />

1994<br />

Epidermolytic hyperkeratosis – verrucous plaques of nipples<br />

Rook p.1506, 1998, Sixth Edition<br />

Erosive adenomatosis (papillary adenomatosis) of the nipple –<br />

blood-stained or serous discharge; enlarged nipple; eroded<br />

nipple; erythema, ulcer, crusted dermatitis, granular<br />

appearance, papule on nipple JAAD 47:578–580, 2002;<br />

JAAD 43:733–751, 2000; superficial papillary adenomatosis of<br />

the nipple JAAD 33:871–875, 1995; JAAD 12:707–715, 1985

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