Dermatologic Differential Diagnosis.pdf. - Famona Site

136 A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1
Job’s syndrome (hyperimmunoglobulin E syndrome) Buckley’s
syndrome) – dermatitis of face, behind ears, scalp, axillae, and
groin; retention of primary teeth with double rows of teeth; deepset
eyes, broad nasal bridge, wide fleshy nasal tip, prognathism,
ocular hypertelorism recurrent bacterial infections of skin with
cold abscesses, contact urticaria, infections of nasal sinuses
and respiratory tract AD 140:1119–1125, 2004; Clin Inf Dis
34:1213–1214,1267–1268, 2002; JAAD S268–269, 2002;
J Pediatr 141:572–575, 2002; NEJM 340:692–702, 1999;
Curr Prob Derm 10:41–92, 1998; Medicine 62:195–208, 1983;
Pediatrics 49:59–70, 1972; Lancet 1:1013–1015, 1966
Kawasaki’s disease
Kindler’s syndrome
Klinefelter’s syndrome – stasis dermatitis
Long arm of chromosome 18 deletions syndrome
Netherton’s syndrome – flexural lichenification; trichorrhexis
invaginata Ped Derm 19:285–292, 2002; AD 135:823–832,
1999; BJD 141:1097–1100, 1999; Curr Prob Derm 10:41–92,
1998; Ped Derm 14:473–476, 1997; Ped Derm 13:183–199,
1996; BJD 131:615–619, 1994
Omenn’s syndrome Acta Derm 782:71, 1988; presents in
neonatal period with atopic-like dermatitis Textbook of Neonatal
Dermatology, p.255, 2001
Powell syndrome – X-linked, intractable diarrhea, autoimmune
polyendocrinopathy, dermatitis, hemolytic anemia Am J Med
Genet 66:378–398, 1996
Rapp–Hodgkin hypohidrotic ectodermal dysplasia – autosomal
dominant; alopecia of wide area of scalp in frontal to crown
area, short eyebrows and eyelashes, coarse wiry sparse
hypopigmented scalp hair, sparse body hair, scalp dermatitis,
ankyloblepharon, syndactyly, nipple anomalies, cleft lip and/or
palate; nails narrow and dystrophic, small stature, hypospadius,
conical teeth and anodontia or hypodontia; distinctive facies,
short stature JAAD 53:729–735, 2005; Ped Derm 7:126–131,
1990; J Med Genet 15:269–272, 1968
Reiter’s syndrome – dermatitis of penis and scrotum Rook
p.2767, 1998; Arthr Rheum 24:844–849, 1981; Semin Arthritis
Rheum 3:253–286, 1974
Richner–Hanhart syndrome (tyrosinemia type II) Curr Prob
Derm 10:41–92, 1998
Say–Barber syndrome – short stature, microcephaly, large ears,
flexion contractures, decreased subcutaneous fat; dermatitis in
infancy with transient hypogammaglobulinemia Am J Med
Genet 86:165–167, 1999
Schopf–Schulz–Passarge syndrome – eyelid cysts (apocrine
hidrocystomas), palmoplantar keratoderma (plantar dermatitis),
hypotrichosis, decreased number of teeth, brittle and furrowed
nails AD 140:231–236, 2004; BJD 127:33–35, 1992;
JAAD 10:922–925, 1984; Birth Defects XII:219–221, 1971
Schwachman’s syndrome – neutropenia, malabsorption, failure
to thrive; generalized xerosis, follicular hyperkeratosis,
widespread dermatitis, palmoplantar hyperkeratosis Ped Derm
9:57–61, 1992; Arch Dis Child 55:531–547, 1980; J Pediatr
65:645–663, 1964
Short stature, mental retardation, facial dysmorphism, short
webbed neck, skin changes, congenital heart disease – xerosis,
dermatitis, low-set ears, umbilical hernia Clin Dysmorphol
5:321–327, 1996
Spondyloepimetaphyseal dysplasia, eczema, and
hypogammaglobulinemia Clin Dysmorphol 8:79–85, 1999
Trichothiodystrophy syndromes – BIDS, IBIDS, PIBIDS –
dermatitis, sparse or absent eyelashes and eyebrows, brittle
hair, premature aging, sexual immaturity, ichthyosis,
dysmyelination, bird-like facies, dental caries;
trichothiodystrophy with ichthyosis, urologic malformations,
hypercalciuria and mental and physical retardation JAAD
44:891–920, 2001; Ped Derm 14:441–445, 1997
Wiskott–Aldrich syndrome – atopic dermatitis,
thrombocytopenia, malignant lymphoma, leukemia Dermatol
Therapy 18:176–183, 2005; Curr Prob Derm 14:41–70, 2002;
Textbook of Neonatal Dermatology, p.255, 2001; Rook
p.700,2746, 1998, Sixth Edition; Int J Dermatol 24:77–81, 1985
TRAUMA
Airbag dermatitis – bizarre shapes of erythema and dermatitis
resembling factitial dermatitis JAAD 33:824–825, 1995
Radiation dermatitis
Radiation recall
Spinal cord injury – nummular dermatitis below the level of
injury AD 83:379–385, 1961
VASCULAR DISEASES
Eczematoid pigmented purpuric eruption
Port wine stain with overlying dermatitis BJD 144:1269–1270,
2001
Post-phlebitic syndrome – pain, edema, night cramps,
hemosiderin deposition, dermatitis Phlebology 11:2–5, 1996
Saphenous vein graft donor site dermatitis Arch Surg 129:609,
1993
Vasculitis simulating eczematous dermatitis – with C2 deficiency
Acta DV 67:265–7, 1987
Venous stasis dermatitis Rook p.659, 1998, Sixth Edition
DERMATITIS, FACIAL, PEDIATRIC
AUTOIMMUNE DISEASES, AND DISEASES
OF IMMUNE DYSFUNCTION
Allergic contact dermatitis
Bare lymphocyte syndrome Rook p.2745, 1998, Sixth Edition
Bruton’s hypogammaglobulinemia – atopic-like dermatitis;
dermatomyositis-like syndrome Rook p.2749, 1998, Sixth
Edition
C3 deficiency – recurrent infections, vasculitis, LE; C3
inactivator deficiency – dermatitis early in infancy Rook p.2744,
1998, Sixth Edition
Chronic granulomatous disease – X-linked or autosomal
recessive, seborrheic dermatitis-like changes, Xp21 (distal end
of Xp), localized pyodermas, abscesses, granulomas, perioral
and intraoral ulcers, lungs/liver/spleen, defect in NADPH oxidase
system; including NADPH, phagocyte cytochrome b, and
cytosolic proteins; membrane-associate NADPH oxidase system
fails to produce superoxide and other toxic oxygen metabolites;
Staphylococcus aureus, Klebsiella, Pseudomonas, Escherichia
coli, Serratia, Aspergillus, Candida, Cryptococcus, Nocardia
DiGeorge’s syndrome (may be same as velocardiofacial
syndrome) – autosomal dominant or sporadic; seborrheic
dermatitis, atopic dermatitis; developmental defects of 3rd and
4th pharyngeal pouches, congenital thymic aplasia, neonatal
tetany due to absence of parathyroids, cardiac anomalies
(truncus arteriosus), short philtrum, low-set malformed ears,
hypertelorism, increased susceptibility to Candida, viral, and
Pneumocystis carinii infections, loss of portion of proximal long
arm of chromosome 22 Rook p.498, 1998, Sixth Edition