Dermatologic Differential Diagnosis.pdf. - Famona Site

296 A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1
Haber’s syndrome – intertriginous pigmentation
Hereditary mucoepithelial dysplasia – psoriasiform intertrigo
Hyper-IgE syndrome (Job’s syndrome) (Buckley’s syndrome) –
papular, pustular, excoriated dermatitis of scalp, buttocks, neck,
axillae, groin; furunculosis; growth failure; dermatitis of face,
behind ears, scalp, axillae, and groin; recurrent bacterial
infections of skin with cold abscesses, contact urticaria,
infections of nasal sinuses and respiratory tract J Pediatr
141:572–575, 2002; NEJM 340:692–702, 1999; Curr Prob
Derm 10:41–92, 1998; Clin Exp Dermatol 11:403–408, 1986;
Medicine 62:195–208, 1983; Lancet 1:1013–1015, 1966
Hyper-IgM syndrome – diaper area ulcers Ped Derm 18:48–50,
2001
Incontinentia pigmenti – hyperpigmentation of axillae and groin
JAAD 47:169–187, 2002
Kawasaki’s disease
Keratosis–ichthyosis–deafness syndrome – exaggerated diaper
dermatitis Ped Derm 13:105–113, 1996; BJD 122:689–697,
1990
Lipoid proteinosis Ghatan p.52, 2002, Second Edition
Netherton’s syndrome – intertrigenous and perigenital
dermatitis, edema, papillomatosis resembling cellulitis
BJD 131:615–621, 1994; JAAD 13:329–337, 1985
Neurofibromatosis type I – Crowe’s sign – intertriginous
pigmentation
Olmsted syndrome – follicular hyperkeratosis of buttocks and
knees; follicular papules; intertrigo, mutilating palmoplantar
keratoderma, linear streaky hyperkeratosis, leukokeratosis of
the tongue, sparse hair anteriorly JAAD 53:S266–272, 2005;
Ped Derm 21:603–605, 2004; Ped Derm 20:323–326, 2003; Eur
J Derm 13:524–528, 2003; BJD 136:935–938, 1997; AD
132:797–800, 1996; AD 131:738–739, 1995; Semin Derm
14:145–151, 1995; JAAD 10:600–610, 1984; Am J Dis Child
33:757–764, 1927
Pseudoxanthoma elasticum – linear and reticulated yellow
papules and plaques JAAD 42:324–328, 2000; Dermatology
199:3–7, 1999; AD 124:1559, 1988
Sjögren–Larsson syndrome – ichthyosis, mental retardation,
spastic diplegia, short stature, kyphoscoliosis, retinal changes,
yellow pigmentation, intertrigo (flexural accentuation), deficiency
of fatty aldehyde dehydrogenase Ped Derm 20:179–180, 2003;
JAAD 35:678–684, 1996
Sweet’s syndrome
Xeroderma pigmentosum – intertriginous pigmentation
TOXIC
Arsenic poisoning – acute; baboon syndrome (anogenital
intertrigo) with intertriginous exanthem BJD 149:757–762, 2003
Methylbromide fumigation – bullae and urticaria
AD 127:917–921, 1991
TRAUMATIC
Child abuse
Friction and bacterial infection
Runner’s rump (intertriginous hyperpigmentation)
JAAD 21:1257–1262, 1989
IRIS LESIONS, PIGMENTED
AUTOIMMUNE DISORDERS, AND DISEASES
OF IMMUNE DYSFUNCTION
Scleroderma – periorbital linear scleroderma associated with
heterochromic iridis Am J Ophthalmol 90:858–861, 1980
INFECTIONS AND INFESTATIONS
Leprosy – leproma
Syphilis – papulat of secondary or tertiary lues
INFILTRATIVE DISEASES
Juvenile xanthogranuloma – iris heterochromia Eye and Skin
Disease, pp.56–57, Lippincott, 1996
INFLAMMATORY DISEASES
Sarcoidal iris granuloma Clin Dermatol 4:129–135, 1986
NEOPLASTIC DISEASES
Aniridia with associated Wilms’ tumor
Benign epithelial melanosis
Conjunctival nevus
Iris freckles
Leiomyoma Rook p.3007, 1998, Sixth Edition
Melanocytic nevus
Melanoma AD 139:1067–1073, 2003
Melanosis oculi
Metastatic melanoma
Iris nevus
Nevus of Ota Dermatol Clin 10:609–622, 1992
Pigmented episcleral spot (Axenfeld’s nerve loop)
Primary acquired melanosis
SYNDROMES
Aniridia with chromosome 18 defects
Cat eye syndrome – iris coloboma with trisomy 22
Down’s syndrome – hypoplastic iris with lighter areas in the
outer third (Brushfield spots) Rook p.373, 1998, Sixth Edition
Incontinentia pigmenti – conjunctival pigmentation
JAAD 47:169–187, 2002
Iris coloboma
4p deletion syndromes
Cat eye syndrome
Chromosome 18 defects (including trisomy 18)
Focal dermal hypoplasia
Linear nevus sebaceus syndrome
Trisomy 22
Iris nevus syndrome (Cogan–Reese syndrome)
Nail–patella syndrome – cloverleaf iris (Lester iris) Rook
p.421, 1998, Sixth Edition
Neurofibromatosis – Lisch nodule NEJM 343:1573, 2000; Rook
p.379, 1998, Sixth Edition; NEJM 324:1264–1266, 1991; J Med
Genet 26:712–721, 1989; Am J Ophthalmol 96:740–742, 1983