Dermatologic Differential Diagnosis.pdf. - Famona Site

322 A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1
Granulation tissue
Orofacial granulomatosis – facial edema with swelling of
lips, cheeks, eyelids, forehead, mucosal tags, mucosal
cobblestoning, gingivitis, oral aphthae; including
Melkersson–Rosenthal syndrome, Miescher’s granulomatous
cheilitis AD 124:1706, 1709, 1988; Crohn’s disease, sarcoid,
allergy to food additives or cobalt BJD 143:1119–1121, 2000;
Rook p.3139–3140, 1998, Sixth Edition; Quintessence
International 28:265–269, 1997; AD 129:477–480, 1993
Pyoderma gangrenosum Br J Plast Surg 53:441–443, 2000;
JAAD 18:559–568, 1988
Pyostomatitis vegetans Rook p.3142, 1998, Sixth Edition
Sarcoid – granulomatous cheilitis AD 141:1085–1091, 2005;
AD 141:1080–1082, 2005; Lupus 1:129–131, 1992;
JAAD 23:444–450, 1990; AD 124:1705–1710, 1988; BJD
115:619–622, 1986; Rook p.2290, 1998, Sixth Edition;
J Oral Surg 34:237–244, 1976
METABOLIC
Congenital neutropenia
Cyclic neutropenia
Cystic fibrosis
Fabry’s disease Ghatan p.76, 2002, Second Edition
Fucosidosis type III
Hunter’s syndrome – X-linked recessive; macrocheilia;
reticulated 2–10 mm skin-colored papules over scapulae,
chest, neck, arms; MPS type II; iduronate-2 sulfatase deficiency;
lysosomal accumulation of heparin sulfate and dermatan
sulfate; short stature, coarse facies, macroglossia, clear
corneas (unlike Hurler’s syndrome), progressive
neurodegeneration, communicating hydrocephalus, valvular
and ischemic heart disease, lower respiratory tract infections,
adenotonsillar hypertrophy, otitis media, obstructive sleep
apnea, diarrhea, hepatosplenomegaly, skeletal deformities
(dysostosis multiplex), widely spaced teeth, dolichocephaly,
deafness, retinal degeneration, inguinal and umbilical hernias
Ped Derm 21:679–681, 2004
Hurler’s syndrome Rook p.3140, 1998, Sixth Edition; Oral Surg
32:46–57, 1971
Hypothyroidism NEJM 283:101, 1970
Lesch–Nyhan syndrome – X-linked recessive;
hypoxanthineguanine phosphoribosyltransferase deficiency;
self-mutilation; biting of lower lip AD 94:194–195, 1966
Vitamin B1 and B2 deficiencies – red lips, angular cheilitis
Ped Derm 16:95–102, 1999; JAAD 15:1263–1274, 1986
NEOPLASTIC
Actinic cheilitis J Derm Surg Oncol 7:289–295, 1981
Epstein–Barr virus associated lymphoproliferative lesions
BJD 151:372–380, 2004
Granular cell schwannoma – linear plaque AD 121:1197–1202,
1985
Kaposi’s sarcoma Rook p.3130, 1998, Sixth Edition
Leukemic macrocheilia – acute myelogenous leukemia
BJD 151:1102, 2004; JAAD 14:353–358, 1986
Leukoplakia
Lymphoma – T-cell lymphoma mimicking Crohn’s disease
Oral Oncol 29B:225–230, 1993
Lymphomatoid granulomatosis (angiocentric lymphoma) –
presenting as angioedema Postgrad Med J 68:366–368, 1992
Melanoma – desmoplastic melanoma of lip; induration and
edema JAAD 47:863–868, 2002
Neurofibroma Rook p.3140, 1998, Sixth Edition
Squamous cell carcinoma
Verrucous carcinoma – oral florid papillomatosis of the lip
BJD 151:727–729, 2004
PARANEOPLASTIC DISEASES
Paraneoplastic pemphigus
PHOTODERMATITIS
Actinic prurigo BJD 144:194–196, 2001; JAAD 44:952–956,
2001; Ped Derm 17:432–435, 2000; JAAD 26:683–692, 1992;
Oral Surg Oral Med Oral Pathol 65:327–332, 1988; Ped Derm
3:384–389, 1986; JAAD 5:183–190, 1981
PRIMARY CUTANEOUS DISEASE
Acanthosis nigricans JAAD 31:1–19, 1994
Acne vulgaris – cyst
Atopic cheilitis Allergy 46:125–128, 1991; Dermatologica
177:360–364, 1988
Cheilitis glandularis (Volkmann’s cheilitis) (Puente’s disease) –
inflammatory condition of the lower lip minor salivary glands;
enlargement with a mucus ductal discharge, crusts and scale
eversion, and hardening of the lip; deep-seated abscesses and
fistulae BJD 148:362, 2003; Oral Surg Oral Med Oral Pathol
78:319–322, 1994; Oral Surg Oral Med Oral Pathol 62:654–656,
1986 J Derm Surg 1:372–375, 1985
Congenital sensory neuropathy with anhidrosis – lip erosions
Ped Derm 11:231–236, 1994
Hydroa vacciniforme – cheilitis with lip ulcers Ped Derm
21:555–557, 2004
Lichen planus
Premature dermatochalasis
SYNDROMES
Ackerman syndrome – taurodontism, pyramidal and fused molar
roots, juvenile glaucoma, unusual upper lip Am J Phys
Anthropol 38:681–694, 1973
Ascher’s syndrome – blepharochalasis with progressive
enlargement of upper lip; increased thickness of eyelids
AD 139:1075–1080, 2003; JAAD 29:650–651, 1993;
Ped Derm 8:122–123, 1991; BJD 66:129–138, 1954;
Klin Monatsbl Augenheilkd 65:86–97, 1920
Beare–Stevenson syndrome – cutis gyrata (furrowed skin),
acanthosis nigricans, hypertelorism, swollen lips, swollen
fingers, prominent eyes, ear anomalies, and umbilical herniation
Skin and Allergy News p.37, Sept 2000
Char syndrome – short philtrum, patulous lips, ptosis, low-set
pinnae Birth Defects 14 (6B):303–305, 1978
Coffin–Lowry syndrome J Med Genet 25:344–348, 1988
Coffin–Siris syndrome Rook p.3140, 1998, Sixth Edition
Cowden’s syndrome
Darier’s disease
Double lip