Dermatologic Differential Diagnosis.pdf. - Famona Site

Type 9 – ACC as feature of malformation syndromes
Trisomy 13 – ACC of scalp with holoprosencephaly, eye
anomalies, cleft lip and/or palate, polydactyly, port wine
stain of forehead Am J Dis Child 112:502–517, 1966
Deletion of short arm of chromosome 4 (4p- syndrome) –
ACC of scalp with hypertelorism, beaked or broad nose,
microcephaly, low-set ears, pre-auricular tags or pits,
mental retardation Am J Dis Child 122:421–425, 1971
Oculocerebrocutaneous syndrome (Delleman–Oorthuys
syndrome) – ACC of scalp, neck, lumbosacral area; orbital
cysts, microphthalmia, skull defects, porencephaly,
agenesis of corpus callosum, skin tags around eyes and
nose Am J Med Genet 40:290–293, 1991
Johanson–Blizzard syndrome – autosomal recessive;
growth retardation, microcephaly, ACC of scalp, sparse
hair, hypoplastic ala nasi, CALMs, hypoplastic nipples and
areolae, hypothyroidism, sensorineural deafness
Clin Genet 14:247–250, 1978
Focal dermal hypoplasia
Facial focal dermal dysplasias
Autosomal dominant focal facial dermal dysplasia without
other facial anomalies – oval symmetrical scarred areas
on temples, cheeks, rim of fine lanugo hairs BJD
84:410–416, 1971
Autosomal recessive focal facial dermal dysplasia
without other facial anomalies JAAD 27:575–58, 1992
Focal facial dermal dysplasia with other facial anomalies
(Setleis syndrome) – leonine aged facies with absent
eyelashes, eyebrows, puckered periorbital skin, scar-like
defects of temples AD 110:615–618, 1974
Amniotic band syndrome
Congenital erosive and vesicular dermatosis with reticulate
supple scarring
Lumpy scalp, odd ears, and rudimentary nipples
BJD 99:423–430, 1978
ACC with nipple and breast hypoplasia, nail dysplasia,
delayed dentition Am J Med Genet 14:381–384, 1983
ACC with tricho-odonto-onychodermal ectodermal dysplasia
BJD 105:371–382, 1981
ACC with EEC Minerva Pediatr 34:627–632, 1982 and
AEC syndromes Ped Derm 10:334–340, 1993
ACC with intestinal lymphangiectasia Am J Dis Child
139:509–513, 1985
ACC with 46,XY gonadal dysgenesis, cleft lip and palate, ear
deformity and pre-auricular pits J Pediatr 97:586–590, 1980
Dellemann syndrome (oculocerebrocutaneous syndrome)
J Med Genet 25:773–778, 1988
Atopic dermatitis
Congenital erosive dermatosis with reticulated supple scarring –
most infants premature; extensive symmetrical erosions with
scattered vesicles; scarring with hypohidrosis, patchy alopecia,
hypoplastic nails AD 126:544–546, 1990
Congenital localized abscence of skin in epidermolysis bullosa
(Bart’s syndrome) AD 128:1087–1090, 1992
Epidermolysis bullosa, multiple types
Erythema of Jacquet – erosive diaper dermatitis; shallow, round
ulcers with raised edges Rook p.470, 1998, Sixth Edition
Febrile ulceronecrotic Mucha–Habermann disease (acute
parapsoriasis) – painful hemorrhagic ulcers BJD 152:794–799,
2005; JAAD 49:1142–1148, 2003; AD 100:200–206, 1969
Lichen planus AD 93:692–701, 1966; ulcerative lichen planus of
the soles Acta DV 81:378–379, 2001; AD 127:405–410, 1991;
Acta DV 66:366–367, 1986; AD 93:692–671, 1966
Lichen sclerosus et atrophicus BJD 144:387–392, 2001
Lichen simplex chronicus
Reactive perforating collagenosis
PSYCHOCUTANEOUS DISEASE
Factitial dermatitis Ped Derm 21:205–211, 2004; NEJM
347:1412–1418, 2002; Klin Wochenschr 64:149–164, 1986;
JAAD 11:1065–1069, 1984; factitial panniculitis – ulcers of the
thigh and buttocks JAAD 2:47–55, 1980
Neurotic excoriations
Self-mutilation
SYNDROMES
ULCERS 659
Acro-osteolysis associated with spinal dysraphism – blister,
ulcers of the foot, hyperhidrosis of the affected limb Ped Derm
18:97–101, 2001
Adams–Oliver syndrome – aplasia cutis congenita of scalp and
transverse limb defects Ped Derm 15:48–50, 1998
Antiphospholipid antibody syndrome NEJM 347:1412–1418,
2002; Semin Arthritis Rheum 31:127–132, 2001; JAAD
36:149–168, 1997; JAAD 36:970–982, 1997; Semin Thromb
Hemost 20:71–78, 1994; JAAD 15:211–219, 1986; eschar and
ulceration JAAD 47:766–769, 2002; IgA antiphospholipid
antibodies J Rheumatol 25:1730–1736, 1998; ulcer resembling
pyoderma gangrenosum J La State Med Soc 147:357–361,
1995; lupus anticoagulant – pyoderma gangrenosum-like
Dermatology 189:182–184, 1994
Ataxia telangiectasia – ulcerated plaque of cutaneous
granuloma of ataxia telangiectasia AD 134:1145–1150, 1998
Behçet’s syndrome – extragenital ulcers JAAD 36:689–696, 1997
Carpal tunnel syndrome Dermatology 201:165–167, 2000
Charcot–Marie–Tooth syndrome – neurotrophic ulcer
Chediak–Higashi syndrome Rook p.2742, 1998, Sixth Edition
Congenital insensitivity to pain Cutis 51:373–374, 1993
Congenital sensory neuropathy with anhidrosis (self-multilation)
AD 124:564–566, 1988
Ectodermal dysplasias
Ehlers–Danlos syndrome
Familial dysautonomia (Riley–Day syndrome)
Flynn–Aird syndrome – skin atrophy, ulceration, alopecia, and
dental caries J Neurol Sci 2:161–182, 1965
Goltz’s syndrome Ghatan p.199, 2002, Second Edition
Hereditary sensory and autonomic neuropathy type I-V
(congenital insensitivity to pain) – ulcers with self-mutilation
Ped Derm 19:333–335, 2002
Hereditary sensory radicular neuropathy
Hyper-IgM syndrome – diaper area ulcers Ped Derm 18:48–50,
2001
Hypereosinophilic syndrome, idiopathic Blood 83:2759–2779,
1994; digital ulcers Semin Dermatol 14:122–128, 1995
Johanson–Blizzard syndrome – aplasia cutis congenita of the
scalp, sparse hair, deafness, absence of permanent tooth buds,
hypoplastic ala nasi, dwarfism, microcephaly, mental
retardation, hypotonia, pancreatic insufficiency with
malabsorption, hypothyroidism, genital and rectal anomalies
Clin Genet 14:247–250, 1978; J Pediatr 79:982–987, 1971
Lesch–Nyhan syndrome – X-linked recessive;
hypoxanthineguanine phosphoribosyltransferase deficiency;
self-mutilation; biting of lower lip AD 94:194–195, 1966
Lumpy scalp syndrome – autosomal dominant; scalp ulcers at
birth heal as irregular scalp nodules; deformed pinnae,
rudimentary nipples Clin Exp Dermatol 15:240, 1989
Marfan-like phenotype – deep skin ulcers JAAD 35:814–818, 1996
Neutrophilic dermatosis (pustular vasculitis of the dorsal hands)
(variant of Sweet’s syndrome) – ulcers AD 138:361–365, 2002