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Dermatologic Differential Diagnosis.pdf. - Famona Site

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258 A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1<br />

Winchester syndrome – thickening, hyperpigmentation and<br />

hypertrichosis, gum and lip hypertrophy, corneal opacities,<br />

musculoskeletal abnormalities Ped Derm 21:154–159, 2004<br />

Xeroderma pigmentosum Rook p.1779, 1998, Sixth Edition<br />

TOXINS<br />

Arsenic – diffuse pigmentation, especially of trunk; with<br />

depigmentation yielding rain-drop appearance Rook p.1785,<br />

1998, Sixth Edition<br />

Eosinophilia myalgia syndrome – L-tryptophan<br />

HYPERPIGMENTATION,<br />

PARONYCHIAL<br />

AIDS<br />

Arsenic poisoning – at 3 months BJD 149:757–762, 2003<br />

AZT<br />

S/P biopsy<br />

Bowen’s disease<br />

Chemotherapy<br />

Congenital nevus<br />

Ethnic pigmentation<br />

Laugier–Hunziker syndrome<br />

Malnutrition<br />

Melanoma – Hutchinson’s sign<br />

Minocycline<br />

Peutz–Jegher syndrome<br />

Pseudo–Hutchinson’s sign<br />

Radiation therapy<br />

Regressing nevoid melanosis of childhood<br />

Subungual hematoma<br />

Trauma<br />

HYPERPIGMENTATION, PATCHY<br />

AUTOIMMUNE DISEASES, AND DISEASES<br />

OF IMMUNE DYSFUNCTION<br />

Allergic contact dermatitis – pigmented poison ivy; pigmentation<br />

due to optical whiteners BJD 81:799–803, 1976; azo-dye<br />

coupling agents Contact Dermatitis 2:129–134, 1976;<br />

fragrances, fungicides Rook p.754, 1998, Sixth Edition<br />

Dermatitis herpetiformis Rook p.1890, Sixth Edition<br />

Dermatomyositis<br />

Graft vs. host disease, chronic – poikilodermatous<br />

hyperpigmentation BJD 92:589, 1975; hyperpigmented macules<br />

with scale (leopard skin) AD 138:924–934, 2002<br />

Lupus erythematosus – melanonychia JAAD 47:S187–188,<br />

2002; neonatal lupus erythematosus; discoid LE<br />

Morphea – linear morphea; morphea profunda with overlying<br />

hyperpigmentation Ped Derm 8:292–295, 1991<br />

Scleroderma, CREST syndrome<br />

Sjögren’s syndrome Ghatan p.175, 2002, Second Edition<br />

CONGENITAL LESIONS<br />

Congenital melanosis and hyperpigmentation Ped Derm<br />

15:290–292, 1998<br />

Congenital smooth muscle hamartoma<br />

Hyperpigmentation of vulva, scrotum, linea nigra, and nails<br />

Eichenfeld p.97, 2001<br />

Normal racial linear brown pigmented bands of nails Ghatan<br />

p.78, 2002, Second Edition<br />

Pigmentary mosaicism – phylloid mosaic pigmentation<br />

Universal acquired melanosis (carbon baby)<br />

DEGENERATIVE DISORDERS<br />

Reflex sympathetic dystrophy JAAD 35:843–845, 1996<br />

DRUGS<br />

ACTH administration<br />

Actinomycin D – brown nails Ghatan p.78, 2002, Second Edition<br />

Adriamycin Ghatan p.6, 2002, Second Edition<br />

Amiodarone – blue–gray pigmentation of sun-exposed areas;<br />

also yellow–brown pigmentation of the cornea JAAD<br />

39:524–525, 1998<br />

Amodaquine<br />

Anthralin – brown or orange nails Ghatan p.78, 2002, Second<br />

Edition<br />

Antimalarials – blue–gray pigmentation of face, neck, forearms,<br />

lower legs AD 88:419–426, 1963; yellow and blue pigmentation<br />

of pretibial areas and hard palate JAAD 39:524–525, 1998;<br />

blue–black pigmentation of skin, face, hard palate, subungually<br />

Rook p.3383, 1998, Sixth Edition<br />

Atabrine (mepacrine) – greenish–yellow pigmentation of face,<br />

hands, feet; then diffuse Am J Med Sci 192:645–650, 1936<br />

AZT – nail and mucous membrane hyperpigmentation Bolognia<br />

p.980, 2003<br />

BCNU topical – hyperpigmentation at site of application<br />

Bolognia p.978, 2003<br />

Birth control pills<br />

Bismuth – generalized hyperpigmentation resembling argyria<br />

and/or blue–black line at the gingival margin JAAD 39:524–525,<br />

1998<br />

Bleomycin – flagellate hyperpigmentation JAAD 39:524–525,<br />

1998; focal hyperpigmentation on elbows, knees, and hands<br />

AD 107:553–555, 1973; palmar creases JAAD 40:367–398,<br />

1999; limited to striae JAAD 28:503–505, 1993; brown nails<br />

Ghatan p.78, 2002, Second Edition<br />

Busulfan Bolognia p.978, 2003; Rook p.3383, 1998, Sixth Edition<br />

Capecitabine acral dysesthesia syndrome – hyperpigmentation<br />

and hyperkeratosis of the dorsal and palmar surfaces of the<br />

hands and feet of blacks Cutis 73:101–106, 2004<br />

Carbidopa – darkening of hair Clin Exp Dermatol 14:317–318,<br />

1989<br />

Carotene Rook p.3383, 1998, Sixth Edition<br />

Chemotherapy – under adhesive bandages after<br />

chemotherapy – linear, annular and diffuse hyperpigmentation<br />

Ped Derm 8:231–235, 1991<br />

Chemotherapy-induced eccrine neutrophilic hidradenitis<br />

JAAD 40:367–398, 1999<br />

Chloroquine<br />

Chlorpromazine – slate-gray hyperpigmentation in sun-exposed<br />

areas JAAD 39:524–525, 1998; longitudinal pigment bands in<br />

neonates of mothers ingesting chlorpromazine Textbook of<br />

Neonatal Dermatology, p.512, 2001<br />

Clofazamine – initially red, then violaceous brown pigmentation<br />

in lesional areas BJD 81:794–795, 1969<br />

Coal tar, topical

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