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Notes<br />
The Pill in Puerto Rico and <strong>the</strong> Mainland United States 181<br />
1. Although U.S. feminists have often picked up <strong>the</strong> Nationalist argument that<br />
<strong>the</strong>re was a U.S. sponsored mass-sterilization campaign on <strong>the</strong> island, <strong>the</strong>re<br />
seems to be little evidence that this was <strong>the</strong> case. Clarence Gamble, on hearing<br />
of <strong>the</strong> accusations that this was taking place, twice sent his own researchers<br />
to <strong>the</strong> island to offer to help fund it. They could not fi nd any organized<br />
campaign for sterilization, and were discouraged by government and public<br />
health offi cials from starting one. See for example Christopher Tietze to<br />
Clarence Gamble, Report 3, September 19, 1946; Report 8, September 25,<br />
1946, Clarence J. Gamble Papers-Countway Library of Medicine, Box 46,<br />
Folder 756 and Wilson Wing to Gamble, May 18, 1951, CJGP-CLM, B47, F774.<br />
Never<strong>the</strong>less, it seems equally clear that <strong>the</strong>re was also a considerable plurality<br />
among physicians who thought sterilization was a good idea for working-class<br />
people on <strong>the</strong> island, and undoubtedly <strong>the</strong>re was improper pressure.<br />
2. Puerto Rican “overpopulation” was everywhere in <strong>the</strong> news; in fact, it was<br />
repeatedly cited as <strong>the</strong> root cause of all <strong>the</strong> economic problems of <strong>the</strong> island.<br />
See “Puerto Rico: Problem Island,” New York Times Magazine, March 7, 1954,<br />
pp. 10–11; Time, May 2 1949, cover article, p. 33; Time, April 23, 1958, cover<br />
article, p. 30; “Growing Pains Beset Puerto Rico,” National Geographic Magazine,<br />
April 1951, p. 24.<br />
3. For examples of this narrative, see esp. <strong>the</strong> popular accounts, Maisel and<br />
Vaughan. Pincus and Rock were also constructing a progesterone story;<br />
<strong>the</strong> name of <strong>the</strong> 1954 project at Rock’s clinic was <strong>the</strong> Pincus Progesterone<br />
Project (<strong>the</strong> PPP, or pee, pee, pee, as it came to be called, for <strong>the</strong> endless urine<br />
collections).<br />
4. This dates back to <strong>the</strong> earliest studies of “organo<strong>the</strong>rapy” by Charles Edouard<br />
Brown-Séquard in <strong>the</strong> late nineteenth century.<br />
5. Anonymous reviewer for “Enovid, Ortho-Novum, and Thromboembolic<br />
Effects,” Medical Letter. Rockefeller Archive Center, Rockefeller University,<br />
Record Group 891, Martin Rizack papers, Box 45, Folder 1.13, March 1963.<br />
6. Ramírez de Arrellano and Seipp, pp. 107–123, report <strong>the</strong> drop-out rate on<br />
<strong>the</strong> Río Piedras series as 109 women out of 221 participants; 22% of <strong>the</strong>se<br />
dropped out because of side effects. For <strong>the</strong> Ryder series, 32.4% of participants<br />
dropped out because of side effects, and 57% total had discontinued after two<br />
years. Adaline Satterthwaite, “Experience,” p. 476.<br />
7. C. Tietze to M. Snyder, August 15, 1957, CLM-CJGP, B48, F788. Gregory<br />
Pincus et al., “Fertility Control with Oral Medication,” American Journal of<br />
Obstetrics and Gynecology, 75 (Aprile 1958): 1333–1346. Oudshoorn criticizes<br />
<strong>the</strong> use of <strong>the</strong> kind of “woman-years” statistic in <strong>the</strong> Pill trials in Puerto Rico.<br />
However, this statistical device was not unique to <strong>the</strong>se trials, but dated back<br />
to <strong>the</strong> 1930s. Its strength was that it enabled researchers to compare divergent<br />
experiences in length of use of a method and made it a simple matter to<br />
deduct, for example, 10 months for a pregnancy or 3 months of a sexual<br />
partners’ absence. Its shortcomings—in overstating researchers’ knowledge<br />
of a method by making 12 women’s experience for one month comparable<br />
to one woman’s experience for a year—were well-known to researchers, and<br />
had spawned a literature of <strong>the</strong>ir own, establishing guidelines such as one<br />
requiring that at least half of any cases reported in this way involve long-term<br />
administration. (See Raymond Pearl in “Contraception and Fertility in 2,000<br />
Women,” Human Biology, 4 (September 1932): 363–407.) Researchers were<br />
aware that <strong>the</strong>re was something wrong with <strong>the</strong> way it was used in <strong>the</strong> Pill<br />
study. Wrote Christopher Tietze, “<strong>the</strong> aggregate number of person years of