You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Beyond X-X and X-Y 285<br />
indicates that <strong>the</strong> genes on <strong>the</strong> second X chromosome that remain<br />
active are not irrelevant leftovers, but play an important role in <strong>the</strong><br />
development and functioning of <strong>the</strong> organism.<br />
The current conception of genetic sex emphasizes <strong>the</strong> differences<br />
between <strong>the</strong> X and Y chromosomes. However, <strong>the</strong>y do share homologue<br />
genes, which in some cases undergo inactivation. Researchers generally<br />
believe that 19 of <strong>the</strong> genes that “escape” inactivation on <strong>the</strong> second<br />
X chromosome have a related DNA sequence on <strong>the</strong> Y chromosome.<br />
While <strong>the</strong> male Y chromosome has been historically characterized as<br />
active, parts of <strong>the</strong> Y chromosome are now known to be inactivated.<br />
One example of this is <strong>the</strong> gene synaptobrevin-like 1 gene, which is<br />
found on <strong>the</strong> X and Y chromosomes. It is inactivated both on <strong>the</strong> second<br />
X chromosome in female X-X cells, and on <strong>the</strong> Y chromosome in male<br />
X-Y cells (Matarazzo, De Bonis, Gregory, et al., 2002). Therefore, <strong>the</strong><br />
same process of silencing or inactivation happens in <strong>the</strong> Y chromosome,<br />
drawing attention to <strong>the</strong> way in which <strong>the</strong> X and Y chromosomes may be<br />
different at <strong>the</strong> karyotype level, yet share similar processes and genes.<br />
In conclusion in <strong>the</strong> current science, X chromosome inactivation<br />
seems to conform neatly to <strong>the</strong> old idea of female as <strong>the</strong> default developmental<br />
pathway, and metaphors, such as “muffl ing,” reinforce <strong>the</strong> old<br />
idea of femininity as something passive and voiceless, and masculinity as<br />
active and vocal. Similarly, <strong>the</strong> notion of “silencing” or “gagging” gives<br />
<strong>the</strong> impression of an “event,” consolidating <strong>the</strong> idea of sex determination<br />
as a decisive happening. However, what is radical about <strong>the</strong> research on<br />
methylation and X chromosome inactivation is that it draws attention<br />
to its processional nature, making sex determination not an event but a<br />
process of sexing <strong>the</strong> early embryo. Additionally, both <strong>the</strong> X chromosome<br />
and <strong>the</strong> Y go through <strong>the</strong> process of methylation; this process is never<br />
complete but results in some of <strong>the</strong> genes on <strong>the</strong> chromosome remaining<br />
active while o<strong>the</strong>rs are inactivated. However, <strong>the</strong> idea of inactivation or<br />
sexing as a precarious and always incomplete process that affects both<br />
<strong>the</strong> X and <strong>the</strong> Y is overlooked when it is explained in <strong>the</strong> historically and<br />
culturally loaded terms of silencing <strong>the</strong> X or <strong>the</strong> woman.<br />
Battle of <strong>the</strong> Sexes<br />
This section explores <strong>the</strong> use of genetic sex as a technology of action,<br />
that is, as a technology that forms identities, agencies, and wills. As<br />
mentioned earlier, technology of action holds human females and males<br />
as distinct biological beings, and indeed in <strong>the</strong> example of <strong>the</strong> Barr body<br />
this is used to govern <strong>the</strong> segregation of <strong>the</strong>ir sport performance. The<br />
difference between women and men has been <strong>the</strong> basis of many popular