Psychiatry - Revue Canadienne de Psychiatrie.2000; 45(2):198.35. Ereshefsky MD, Watanabe MD, Tran-JohnsonTK. Clozapine: an atypical antipsychoticagent. Clin Pharm. 1989; 8: 691-709.36. Essock SM, Hargreaves WA, Covell NH, GoetheJ. Clozapine’s effectiveness for patientsin state hospitals: results from a randomizedtrial. Psychopharmacol Bull. 1996; 32: 683-697.37. Evins AE, Goff DC. Adjunctive antidepressantdrug therapies in the treatment of negativesymptoms of shizophrenia. CNS Drugs. 1996Aug; 6(2): 130-147.38. Evins AE, Fitzgerald SM, Wine L, Rosselli R,Goff DC. Placebo controlled trial of glycineadded to clozapine in schizophrenia. Am JPsychiatry. 2000; 157:826–828.of schizophrenic patients": Reply. Am JPsychiatry. 1991; 148(2): 275-276.45. Goff DC, Henderson DC, Evins AE, Amico E. Aplacebo-controlled crossover trial of D-cycloserineadded to clozapine in patients withschizophrenia. Biol Psychiatry. 1999; 45: 512–514.46. Greenwood-Smith C. Serum clozapine levels:review of their clinical utility. J Psichopharmacol.2003; 17: 234-238.47. Growe GA, Crayton JW, Klass DB, Evans H,Strizich M. Lithium in chronic schizophrenia.Am J Psychiatry. 1979; 136:454-5.48. Guitton C ,Kinowski, Abbar M, Chabrand P,Bressolle F. Clozapine and metabolite concentrationsduring treatment of patientswith chronic schizophrenia. J Clin Pharmacol.1999; 39: 721-728.39. Faisal I, Lindenmayer JP, Taintor Z, Cancro R.Clozapine-benzodiazepine interactions. JClin Psychiatry. 1997; 58(12):547-8.40. Falkai P, Wobrock T, Lieberman J, Glenthoj B,Gattaz WF, Möller HJ. WFSBP Task Force onTreatment Gidelines for Schizophrenia WordFederation of Societies of biologicalPsychiatry (WFSBP) Guidelines for biologicaltreatment of schizophrenia, Part 2: LongTerm treatment of schizophrenia. World JBiol Psychiatry. 2006; 7(1): 5-40.41. Fleischhacker WW, Hummer M, Kurtz M et al.Clozapine dose in the United States and Europe:implications for Therapeutic and adverseeffects. J Clin Psychiatry. 1994; 55(suppl B): 78-81.42. Grabowski J. Clonidine treatment of clozapinainduced hypersalivation (letter). J ClinPsychopharmacol. 1992; 12: 69-70.43. Gerlach J, Lublin H, Peacock L. Extrapiramidalsymptoms during long-term treatment withantipsychotics, special focus on clozapina andD1 and D2 dopamine antagonists. Neuropsychopharmacology.1996; 14 (Suppl. 3): 35-39.44. Goff DC, Brotman AW, McCormick S, WaitesM et al. Addition of fluoxetine to treatment49. Haack MJ et al. Toxic rise of clozapina plasmaconcentrations in relation to inflammation.Eur neuropsychopharmacol. 2003; 13: 381-385.50. Haller E, Binder RL. Clozapine and seizures.Am J Psychiatry. 1990; 147(8): 1.069-1.071.51. Haring C, Meise U, Humpel C, Saria A, FleischhackerWW, Hinterhuber H. Dose-relatedplasma levels of clozapine: influence of smokingbehaviour, sex and age Psychopharmacology.1989; 99 Suppl: S38-S40.52. Haring C, Fleischhacker WW, Schett P, HumpelC, Barnas C, Saria A. Influence of patientrelatedvariables on clozapine plasma levels.Am J Psychiatry. 1990; 147: 1.471-1.475.53. Hasegawa M, Gutierrez-Esteinou R, Way L,Meltzer HY. Relationship between clinical efficacyand clozapine concentrations inplasma in schizophrenia: effect of smoking.J Clin Psychopharmacol. 1993; 13: 383-390.54. Heresco-Levy U, Javitt DC, Ermilov M, MordelC, Horowitz A, Kelly D. Double-blind, placebo-controlled,crossover trial of glycine adjuvanttherapy for treatment-resistantschizophrenia. Br J Psychiatry. 1996; 169:610–617.esTRaTegIas111
ESTRATEGIAS TERAPÉUTICAS EN LA ESQUIZOFRENIA REFRACTARIA O ESQUIZOFRENIA RESISTENTE AL TRATAMIENTO55. Heresco-Levy U, Javitt DC, Ermilov M, MordelC, Silipo G, Lichtenstein M. Efficacy of highdoseglycine in the treatment of enduringnegative symptoms of schizophrenia. ArchGen Psychiatry. 1999; 56: 29–36.56. Hogarty GE, McEvoy JP, Ulrich RF, DiBarry AL,Bartone P, Cooley S, Hammill K, Carter M, Mu<strong>net</strong>zMR, Perel J. PharmacotherapyPsychiatry. 1995; 52: 29–41.57. Hinkes R, Quesada TV, Currier MV, GonzalezBlanco M. Aspiration pneumonia possibly secondaryto clozapine-induced sialorrea (letter).J Clin Psychopharmacol. 1996; 16:462-463.58. Hirsch S, Weinberger D. Schizophrenia 2thedition. (Ed Blackwell Science). 2003.59. Honigfeld G, Arellano F, Sethi J, Bianchini A,Eschein J. Reducing clozapina-related morbidituand mortality: 5 years experience withthe Clozaril national registry. J ClinPsychiatry. 1998; 59 Suppl. 3: 3-7.60. Iqbal MM, Rahman A, Husain Z, MahmudSZ, Ryan WG, Feldman JM. Clozapine: a clinicalreview of adverse effects and management.Ann Clin Psychiatry. 2003; 15:33-48.61. Javitt DC, Zylberman I, Zukin SR, Heresco-Levy U, Lindenmayer JP. Amelioration of negativesymptoms in schizophrenia byglycine. Am J Psychiatry. 1994; 151: 1.234–1.236.62. Javitt DC, Silipo G, Cienfuegos A, Shelley AM,Bark N, Park M, Lindenmayer JP, Suckow R,Zukin SR. Adjunctive high-dose glycine inthe treatment of schizophrenia. Int J Neuropsychopharmacol.2001; 4: 385–391.63. Kando JC, Tohen M, Castillo J, Centorrino F.Concurrent use of clozapine and valproate inaffective and psychotic disorders. J ClinPsychiatry. 1994; 55(6): 255-7.64. Kane J, Honigfeld G, Singer J, Meltzer H, andthe clozaril collaborative study group Clozapinefor the treatment-resistant schizophrenic.A duble-blind comparison withclozapina. Arch Gen Psychiatry. 1988; 45:789-796.65. Kane JM, Leucht S, Carpenter D, Docherty JP.Expert Consensus Panel for Optimizing PharmacologicTreatment of Psychotic Disorders.The expert consensus guideline series. Optimizingpharmacologic treatment of psychoticdisorders. Introduction: methods,commentary, and summary. J Clin Psychiatry.2003; 64 (Suppl 12): 5-19.66. Keefe R, Silva S, Perkins D. The effects of atypicalantipsychotic drugs on neurocognitiveimpairment in schizophrenia: a review andmeta-analysis. Schizophr Bull. 1999; 25: 201-222.67. Kellner M, Wiedermann K, Krieg JC, Berg PA.Toxic hepatitis by clozapina treatment (letter).Am J Psychiatry. 1993; 150: 985-986.68. Kilian JG, Kerr K, Lawrence C, Celermajer DS.Myocarditis and cardiomyopathy associatedwith clozapine. Lancet. 1999; 354 (9.193):1.841-5.69. Klein DF, Davis JM. Diagnosis and Drug Treatmentof Psychiatric Disorders. Baltimore:Williams & Wilkins. 1969.70. Kontaxakis V P, Ferentinos PP, Havaki-KontaxakiBJ, Roukas DK. Randomized controlledaugmentation trials in clozapine resistantschizophrenic patients: a critical review. EurPsychiatry. 2005; 20: 409-415.71. Kremer I, Vass A, Gorelik I, Bar G, Blanaru M,Javitt DC et al. Placebo-controlled trial of lamotrigineadded to conventional and atypicalantipsychotics in schizophrenia. BiolPsychiatry. 2004; 56(6): 441-6.72. Kronig MH, Munne RA, Szymanski S, SaffermanAZ, Pollack S, Cooper T, Kane JM, LiebermanJA. Plasma clozapine levels and clinicalresponse for treatment-refractory schizophrenicpatients. Am J Psychiatry. 1995; 152:179-182.73. Krupp P, Barnes P. Leponex-associated granulocitopenia:a review of the situation.Psychopharmacology. 1989; 99 (Suppl.): 118-121.74. Kurz M, Hummer M, Oberbauer H et al. Extrapyramidalside effects of clozapine and112
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RESUMEN ESTRUCTURADOTítulo:ESTRATE
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RESULTADOSLa guía propone criterio
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Zenbait egile tratamendu antipsikot
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STRUCTURED SUMMARYTitle:THERAPEUTIC
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RESULTSThe guideline proposes remis
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1.1. INTRODUCCIÓN a la esqUIzOfReN
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dos en el consenso del propio grupo
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precoz que las mujeres (aproximadam
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21. Johnstone EC, MacMillan EJ, Fri
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2. OBJETIVOS
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3. METODOLOGÍA
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4. ESTRATEGIAS DE TRATAMIENTOFARMAC
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domizados con placebo, siendo en ca
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Tabla estudios comparativos asg ver
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4.1.4. estudios comparativos de efi
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6. Gilbert PL, Harris MJ, McAdams L
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Si bien persisten dudas sobre si su
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De todos estos estudios se deduce u
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se debe ser cauto a la hora de atri
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5. Cather C, Penn D, Otto M, Yovel
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41. Tarrier N, Beckett R, Harwood S
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2. No hay evidencias que apoyen o r
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enia. A meta-analysis. Schizophr. B
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geneidad de modelos de tratamiento,
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económicos (homeless). La eficacia
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5.7. teRapiaS De GRupo5.7.1. introd
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5.7.6. bibliografía1. American Psy
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quizofrenia. Este grupo ha identifi
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fue que la rehabilitación neuropsi
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17. Pilling S, Bebbigton P, Kuipers
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de estudios con cierta antigüedad.
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6. Gunderson JG, Frank AF, Katz HM,
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emociones intensas puedan ser expre
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Los informes clínicos sugieren que
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tores solo han encontrado un solo e
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9. Payne H. Dance movement therapy-
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No existiendo un consenso actual so
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7. ANEXO
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isperidona vs APGVariables k Total
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isperidona vs HaloperidolVariables
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Tabla 2-5. Estudios comparativos an
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Tabla 3-2. Estudios comparativos ri
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Tabla 5-1. Estudios con carbamazepi
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Tabla 5-3. Estudios con Antidepresi
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Tabla 5-5. Estudios con β-bloquean
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Tabla 5-8. Estudios con litio como
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Tabla 6-2. Estudios comparativos de
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Tabla 7-2. Comparación TEC+ antips
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.../...TamañoAutores Estudio Carac
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.../...TamañoAutores Estudio Carac
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Tabla 9-2. EMT para tratamiento de
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Tabla 9-5. Tabla COrdES J. (2006) (
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Tabla 10-1. Comparación de entrena
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Tabla 11-1. Metanálisis y revision
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.../...nº rCT n rr (IC) NNT (IC) W
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Tabla 12-4. Comparación Terapia Co
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.../...Autores Estudio Característ
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Tabla 14-3. Estudios con Tratamient
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Tabla 14-5. Estudios con Terapia As
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ESTRATEGIAS TERAPÉUTICAS EN LA ESQ
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Tabla 16-2. Psicoterapia psicodiná
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Tabla 17-1. Metanálisis sobre la e