haloperidol. Psychopharmacology. 1995;118: 52-56.75. Lee SH, Yang YY. Reversible neurotoxicity inducedby a combination of clozapine and lithium:a case report.Chung Hua i Hsueh TsaChih - Chin Med J. 1999; 62(3): 184-7.76. Lieberman JA, Kane JM, Jhons CA. Clozapine:Guidelines for clinical management. J ClinPsychiatry. 1989; 50: 329-338.77. Lieberman JA, Yunis J, Egea E et al. HLA-B38,DR4, DQW 3 and clozapina-induced agranulocitosisin jewish patients with schizophrenia.Arch Gen Psychiatry. 1990; 47: 945-948.78. Lieberman JA, Saffeman AZ, Pollack S,Szymanski S, Johns C, Howard A, Kronig M,Bookstein P, Kane JM. Clinical effects of clozapinein chronic schizophrenia: response totreatment and predictors of outcome. Am JPsychiatry. 1994; 151: 1.744-1.752.79. Lieberman JA. Maximizing clozapine therapy:managing side effects. J Clin Psychiatry.1998; 59 (suppl 3): 38-43.80. Lindenmayer JP, Gochowski S, Mabugat L.Clozapine effects on positive and negativesymptoms: a six month trial in treatment-refractoryschizophrenic. J Clin Psychopharmacol.1994; 14: 201-2<strong>04.</strong>81. Llorca PM, Lancon C, Disdier B , Farisse J,Sapin C, Auquier P. Effectiveness of clozapinein neuroleptic-resistant schizophrenia: clinicalresponse and plasma concentrations.JPsychiatry Neurosci. 2002; 27 (1): 30-7.82. Llorca PM, Pere JJ. Leponex 10 ans après-Unerevue Clinique L’Encephale. 2004; XXX: 474-91.85. McEvoy y cols. Treatment of schizophrenia1999. The expert consensus guideline series.J Clin Psychiatry. 1999; 60 Suppl 11: 3-80.86. McEvoy JP, Lieberman JA, Stroup TS, DavisSM, Meltzer HY, Rosenheck RA, Swartz MS,Perkins DO, Keefe RSE, Davis CE, Severe J,Hsiao JK, for the CATIE Investigators. Effectivenessof clozapine versus olanzapine, quetiapine,and risperidone in patients withchronic schizophrenia who did not respondto prior atypical antipsychotic treatment. AmJ Psychiatry. 2006; 163: 600-610.87. Meltzer HY, Bastani B, Kwon KY, Ramirez LF,Bur<strong>net</strong>t S, Sharpe J. A prospective study ofclozapine in treatment-resistant schizophrenicpatients.I Preliminary Report. Psychopharmacology(Berlin). 1989; 99 Suppl:S68-72.88. Metzer HY. The effect of clozapine and otheratypical antipsychotic drugs on negativesymptoms. In Marneros A, Andreasen NC,Tsuang MT eds, negative versus Positiveschizophrenia (Springer-Verlag: Heidelberg1991). 1991; 365-75.89. Meltzer HY. Treatment of the neurolepticnonresponsiveschizophrenic patient. SchizophrBull. 1992;18: 515-542.90. Meltzer HY, McGurk SR. The effects of clozapina,risperidona and olanzapine on cognitivefunction in schizophrenia. SchizophrBull. 1999; 25: 233-255.91. Meltzer HY & Okayli G. Reduction of suicidalityduring clozapina treatment of neuroleptic-resistantschizophrenics: impact on riskbenefit assessment. Am J Psychiatry. 1995;152: 183-190.esTRaTegIas83. Longo LP, Salzman C. Valproic acid effectson serum concentrations of clozapine andnorclozapine. Am J Psychiatry. 1995; 152(4):650.84. Marder SR, Essock SM, Miller AL, BuchananRW, Davis JM, Kane JM, Lieberman J, SchoolerNR. The Mount Sinai Conference on thePharmacotherapy of schizophrenia. SchizophrBull. 2002; 28(1): 5-16.92. Meltzer HY, Alphs L, Green AI, Altamura C,Anand R, Bertoldi A, Bourgeois M, Chouinard G,Islam MZ, Kane J, Krishnan R, Lindenmayer JP,Potkin S, for the InerSePT Study Group. Clozapi<strong>net</strong>reatment for suicidality in schizophrenia.International suicide prevention trial (Inter-SePT) Arch Gen Psychiatry. 2003; 60: 82-91.93. Meyer JM [Ed], Nasrallah HA [Ed]. Medical ilnessand schizophrenia (2nd ed.). xvi, 455 pp.113
ESTRATEGIAS TERAPÉUTICAS EN LA ESQUIZOFRENIA REFRACTARIA O ESQUIZOFRENIA RESISTENTE AL TRATAMIENTOArlington, VA, US: American Psychiatric Publishing,Inc. US; 2009. p.169-202.94. Miller DD, Pery PJ, Cardoret RJ, AndreasenNC. Clozapine’s effect on negativesymptoms in treatment refractory schizophrenics.Compr Psychiatry. 1994; 35: 8-15.95. Miller DD, Fleming F, Holman TL y cols.Plasma Clozapine concentrations as a predictorof clozapine response: a follow-upstudy. J Clin Psychiatry. 1994; 61( suppl 8):14-19.96. Miller DD. The clinical use of clozapineplasma concentrations in the managementof treatment-refractory schizophrenia. AnnClin Psychiatry. 1996; 8: 99-109.97. Moore TA and the group for the Texas MedicationAlgorithm project (TMAP). AntipsychoticAlgorithm for Schizophrenia: 2006Update. J Clin Psychiatry. 2007; 68: 1.751-1.762.98. Moncrieff J. Clozapine v conventional antipsychoticdrugs for treatment-resistantschizophrenia: a re-examination. Br JPsychiatry. 2003; 183: 161-166.99. Mouaffak F, Tranulis C, Gourevitch R, PoirierMF, Douki S, Olie JP, Loo H, Gourion D. Augmentationstrategies of clozapine with antipsychoticsin the treatment ofultraresistant schizophrenia Clin neuropharmacol.2006; 29: 28-33.100. Mukherjee S, Decina P, Boccola V, SaraceniF & Scapicchio P. Diabetes mellitus in schizophreniapatients. Compr Psychiatry. 1996;37: 68-73.101. National Institute for Health and Clinical Excellence(NICE). Schizophrenia. Core interventionsin the treatment andmanagement of schizophrenia in primaryand secondary care (update). Guide nº 82.2009 March.102. Ng CH et al. An inter-ethnic comparisonstudy of clozapina dosage, clinical responseand plasma levels. Int Clin Psychopharmacol.2005; 20:163-168.103. Pickar D, Owen RR, Litman RE, Konicki E,Gutierrez R and Rapaport MH. Clinical andbiologic response to clozapine in patientswith schizophrenia. Crossover comparisonwith fluphenazine Section on Clinical Studies,National Institute of Mental Health,Bethesda, Md. 20892. 1992.1<strong>04.</strong> Perry PJ, Miller DD, Arndt SV et al. Clozapineand norclozapine plasma concentrationsand clinical response of treatment-refractoryschizophrenic patients. Am JPsychiatry. 1991; 148: 231-235.105. Perry PJ. Therapeutic drug monitoring ofantipsychotics. Psychopharmacol Bull.2001; 35: 19-29.106. Potkin SG, Jin Y, Bunney BG, Costa J, GulasekaramB. Effect of clozapine and adjunctivehigh-dose glycine intreatment-resistant schizophrenia. Am JPsychiatry. 1999; 156(1): 145-7.107. Potkin SG, Bera R, Gulasekaram B. Plasmaclozapine concentrations predict clinicalresponse in treatment-resistant schizophrenia.J Clin Psychiatry. 1994; 55 (9 suppl B):133-136.108. Rosenheck R, Cramer J, Xu W et al. A comparisonof clozapina and haloperidol in hospitalisedpatients with refractoryschizophrenia. N Eng J Med. 1997; 337: 809-815.109. Rosenheck R, Dunn L Peszke M, Cramer J,Xu W, Thomas J, Charney D and the Departmentof Veterans Affairs Cooperative StudyGroup on Clozapine in Refractory Schizophrenia.Impact of Clozapine on NegativeSymptoms and on the Deficit Syndrome inRefractory Schizophrenia. Am J Psychiatry.1999; 156: 88–93.110. Rostami-Hodjegan A, Amin AM, Spencer EP,Lennard MS, Tucker GT, Flanagan RJ. Influenceof dose, cigarette smoking, age, sexand metabolic activity on plasma concentrations:a predictive model and nomograms toaid clozapine dose adjustement and to assesscompliance in individual patients. J ClinPsychopharmacol. 2004; 24: 70-78.114
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RESUMEN ESTRUCTURADOTítulo:ESTRATE
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RESULTADOSLa guía propone criterio
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Zenbait egile tratamendu antipsikot
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STRUCTURED SUMMARYTitle:THERAPEUTIC
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RESULTSThe guideline proposes remis
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1.1. INTRODUCCIÓN a la esqUIzOfReN
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dos en el consenso del propio grupo
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precoz que las mujeres (aproximadam
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21. Johnstone EC, MacMillan EJ, Fri
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2. OBJETIVOS
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3. METODOLOGÍA
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4. ESTRATEGIAS DE TRATAMIENTOFARMAC
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domizados con placebo, siendo en ca
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Tabla estudios comparativos asg ver
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4.1.4. estudios comparativos de efi
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6. Gilbert PL, Harris MJ, McAdams L
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Si bien persisten dudas sobre si su
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De todos estos estudios se deduce u
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se debe ser cauto a la hora de atri
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ESTRATEGIAS TERAPÉUTICAS EN LA ESQ
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41. Tarrier N, Beckett R, Harwood S
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Los estudios excluidos fueron los d
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2. No hay evidencias que apoyen o r
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enia. A meta-analysis. Schizophr. B
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geneidad de modelos de tratamiento,
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económicos (homeless). La eficacia
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5.7. teRapiaS De GRupo5.7.1. introd
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5.7.6. bibliografía1. American Psy
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quizofrenia. Este grupo ha identifi
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fue que la rehabilitación neuropsi
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17. Pilling S, Bebbigton P, Kuipers
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de estudios con cierta antigüedad.
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emociones intensas puedan ser expre
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Los informes clínicos sugieren que
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9. Payne H. Dance movement therapy-
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No existiendo un consenso actual so
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7. ANEXO
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isperidona vs APGVariables k Total
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isperidona vs HaloperidolVariables
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Tabla 2-5. Estudios comparativos an
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Tabla 3-2. Estudios comparativos ri
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Tabla 5-1. Estudios con carbamazepi
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Tabla 5-3. Estudios con Antidepresi
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Tabla 5-5. Estudios con β-bloquean
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Tabla 5-8. Estudios con litio como
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Tabla 6-2. Estudios comparativos de
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Tabla 7-2. Comparación TEC+ antips
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.../...TamañoAutores Estudio Carac
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.../...TamañoAutores Estudio Carac
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Tabla 9-2. EMT para tratamiento de
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Tabla 9-5. Tabla COrdES J. (2006) (
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Tabla 10-1. Comparación de entrena
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Tabla 11-1. Metanálisis y revision
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.../...nº rCT n rr (IC) NNT (IC) W
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Tabla 12-4. Comparación Terapia Co
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.../...Autores Estudio Característ
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Tabla 14-3. Estudios con Tratamient
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Tabla 14-5. Estudios con Terapia As
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ESTRATEGIAS TERAPÉUTICAS EN LA ESQ
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Tabla 16-2. Psicoterapia psicodiná
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Tabla 17-1. Metanálisis sobre la e