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Gilbert's disease, drug-induced hyperbilirubinemia or extra-hepatic cholestasis and elevated
bilirubin (> 17 µmol/l) and/or GGT (> normal).
APRI failure was considered when abnormally normal values of AST could lead to the
underestimation of fibrosis (24).
Lastly, FS failure was considered when FS result did not comply with fixed criteria
(success rate 30 % of the median value) and was considered as unreliable.
Attribution of discordances
Discordances were classified as highly or moderately attributable to each of the tests
analyzed as follows:
- Discordance was considered as highly attributable to FT or APRI failure if (a) results
of FT or APRI were ≤F3 and result of FS was F4, in the presence of a decompensated liver
disease (ascites, hepatic encephalopathy or bleeding varices) or at least two criteria of
cirrhosis (splenomegaly, reduction or reversal portal flow, portosystemic derivation, repermeabilization
of umbilical vein, grade 2 or 3 oesophageal varices, portal hypertensive
gastropathy or low PT ratio [