Télécharger le texte intégral

In conclusion, this prospective study on a large cohort of patients co-infected with HIV and
HCV indicates that FT, FS and APRI, taken two by two, provide concordant results for the
diagnosis of cirrhosis in 78 to 87% of patients, rendering liver biopsy unnecessary in the vast
majority of cases. However the need of liver biopsy could remain when potential risk factors
for discordance exist or when a discordance is unexplained.
In clinical practice, careful examination for the presence of potential factors leading to
discordant results is required before performing non-invasive scores. Further validation
studies are needed to combine non-invasive scores for determining an optimal algorithm in
HIV-HCV coinfected patients.
Acknowledgements: This study is sponsored and funded by the French National Agency for
Research on Aids and Viral Hepatitis (ANRS), with the participation of Abbott France, Glaxo-
Smith-Kline, Roche and Schering-Plough, and INSERM ’s “Programme cohortes TGIR”.
19