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Table 2 : Univariate and multivariate analyses of factors associated with discordance
for the diagnosis of cirrhosis between Fibrotest and Fibroscan (Diagnostic cut-offs:
FT≥0.75; FS >12.5kPa), ANRS CO 13 HEPAVIH, 2006-2009
Univariate analyses
Multivariate analyses
(final model)
OR (95% CI) p OR (95% CI) p
Age>45 years* 2.1 (1.3-3.5) 0.003
Male gender* 4.6 (2.3-9.3) 28 (kg/m 2 ) 1.4 (0.6-3.3) 0.43
Waist circumference (cm/5)* 1.2 (1.1-1.3) 0.007
Lipodystrophy* 1.6 (1.0-2.7) 0.048 2.1 (1.1-4.2) 0.03
atrophy 1.5 (0.9-2.6) 0.09
hypertrophy 1.7 (1.0-2.9) 0.05
Alcohol >50 (g/d)* 2.6 (1.1-6.1) 0.02
HCV genotype : 1 or 4 vs other 1.1 (0.6-2.1) 0.74
CD4 cell count (mm 3 ) 1.0 (0.9-1.0) 0.29
ALTxULN (IU/L)* 1.1 (1.0-1.3) 0.03
ASTxULN (IU/L) 1.2 (1.1-1.4) 0.003
Bilirubin>17 (µmol/L)* 2.0 (1.2-3.2) 0.008 2.7 (1.4-5.3) 0.003
γGT > 1.5N (IU/L)* 2.4 (1.5-4.1) 0.0006 2.3 (1.2-4.5) 0.01
α2–macroglobulin >3 (g/L) * 5.4 (3.0-9.6)