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Table 3 : Univariate and multivariate analyses of factors associated with discordance
for the diagnosis of cirrhosis between FibroTest and APRI (Diagnostic cut-offs:
FT≥0.75; APRI >2), ANRS CO 13 HEPAVIH, 2006-2009
Univariate analyses
Multivariate analyses
(final model)
OR (95% CI) p OR (95% CI) p
Age >45 years* 2.1 (1.3-3.5) 0.004 2.1 (1.1-4.0) 0.03
Male gender* 4.2 (2.1-8.5) 28 (kg/m 2 ) 1.7 (0.7-3.9) 0.25
Waist circumference (cm/5)* 1.2 (1.1-1.4) 0.001
Lipodystrophy 1.4 (0.9-2.4) 0.16
atrophy 1.3 (0.8-2.3) 0.25
hypertrophy 1.6 (0.9-2.8) 0.08
Alcohol >50 (g/d) 1.2 (0.5-3.2) 0.68
HCV genotype : 1 or 4 vs other 1.2 (0.6-2.3) 0.52
CD4 cell count (mm 3 ) 1.0 (0.9-1.0) 0.40
ALTxULN (IU/L)* 1.0 (0.9-1.1) 0.86
ASTxULN (IU/L) 1.0 (0.9-1.2) 0.81
Bilirubin>17 (µmol/L)* 2.8 (1.7-4.6) 1.5N (IU/L)* 2.5 (1.5-4.2) 0.0007 2.4 (1.2-4.8) 0.01
α2–macroglobulin>3 (g/L)* 5.7 (3.1-10.6)