Tesis Doctoral Xi, L., Feber, A., Gupta, V., Wu, M., Bergemann, A.D., Landreneau, R.J., Litle, V.R., Pennathur, A., Luketich, J.D., and Godfrey, T.E. (2008). Whole genome exon arrays i<strong>de</strong>ntify differential expression of alternatively spliced, cancer-‐related genes in lung cancer. Nucleic Acids Res 36, 6535-‐6547. Xie, X.L., and Beni, G. (1991). A validity measure for fuzzy clustering. IEEE Transactions on Pattern Analysis and Machine Intelligence 13, 841-‐847. Yates, T., Okoniewski, M.J., and Miller, C.J. (2008). X:Map: annotation and visualization of genome structure for Affymetrix exon array analysis. Nucleic Acids Res 36, D780-‐786. Zhan, F., Hardin, J., Kordsmeier, B., Bumm, K., Zheng, M., Tian, E., San<strong>de</strong>rson, R., Yang, Y., Wilson, C., Zangari, M., et al. (2002). Global gene expression profiling of multiple myeloma, monoclonal gammopathy of un<strong>de</strong>termined significance, and normal bone marrow plasma cells. Blood 99, 1745-‐1757. Zhan, F., Huang, Y., Colla, S., Stewart, J.P., Hanamura, I., Gupta, S., Epstein, J., Yaccoby, S., Sawyer, J., Burington, B., et al. (2006). The molecular classification of multiple myeloma. Blood 108, 2020-‐2028. Zhan, F., Tian, E., Bumm, K., Smith, R., Barlogie, B., and Shaughnessy, J., Jr. (2003). Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-‐stage B-‐cell <strong>de</strong>velopment. Blood 101, 1128-‐1140. Zhang, L., and Li, W.H. (2004). Mammalian housekeeping genes evolve more slowly than tissue-‐specific genes. Mol Biol Evol 21, 236-‐239. 114
Apéndice Apéndice Publicaciones científicas realizadas durante el <strong>de</strong>sarrollo <strong>de</strong> la presente Tesis Doctoral Publicaciones relacionadas con el Capítulo 1 – <strong>Risueño</strong>, A., Fontanillo, C., Dinger, M.E., and De Las Rivas, J. (2010). GATExplorer: genomic and transcriptomic explorer; mapping expression probes to gene loci, transcripts, exons and ncRNAs. BMC Bioinformatics 11, 221. Publicaciones relacionadas con el Capítulo 2 – Gutiérrez, N.C., Sarasquete, M.E., Misiewicz-‐Krzeminska, I., Delgado, M., De Las Rivas, J., Ticona, F.V., Fermiñán, E., Martín-‐Jiménez, P., Chillón, C., <strong>Risueño</strong>, a., et al. (2010). Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling. Leukemia 24, 629-‐637. – Rodriguez, A.E., Hernan<strong>de</strong>z, J.A., Benito, R., Gutierrez, N.C., Garcia, J.L., Hernan<strong>de</strong>z-‐Sanchez, M., Risueno, A., Sarasquete, M.E., Ferminan, E., Fisac, R., et al. (2012). Molecular characterization of chronic lymphocytic leukemia patients with a high number of losses in 13q14. PLoS One 7, e48485. Publicaciones relacionadas con el Capítulo 3 – <strong>Risueño</strong>, A., et al. (2013). Robust estimation of gene and exon expression to i<strong>de</strong>ntify alternative splicing events: a method applied to human tissue genes. En preparación Publicaciones relacionadas con el Capítulo 4 – Prieto, C., <strong>Risueño</strong>, A., Fontanillo, C., and De Las Rivas, J. (2008). Human Gene Coexpression Landscape: Confi<strong>de</strong>nt Network Derived from Tissue Transcriptomic Profiles. PLoS One 3, e3911. Otras publicaciones – Rodríguez, A.E., Robledo, C., García, J.L., González, M., Gutiérrez, N.C., Hernán<strong>de</strong>z, J.A.M., Sandoval, V., García <strong>de</strong> Coca, A., Recio, I., <strong>Risueño</strong>, A., et al. (2012). I<strong>de</strong>ntification of a novel recurrent gain on 20q13 in chronic lymphocytic leukemia by array CGH and gene expression profiling. Annals of Oncology 23, 2138-‐2146. 115
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Bioinformática aplicada a estudios
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Índice INTRODUCCIÓN GENERAL .....
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Introducción general Bioinformáti
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