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Contribution à l'étude de virus de mollusques marins apparentés ...

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Our plans for testing this la st hypothesis will probably indicate the mechanisms of transmission of the<br />

disease and its relations to temperature or other stressors. We expect to establish a breeding<br />

procedure that cou Id avoid the production and dissemination of larvae carrying the <strong>virus</strong>, susceptible to<br />

<strong>de</strong>veloping the disease in a later spat stage or transmitting the herpes-like <strong>virus</strong> to their progeny. Our<br />

future prospects also inclu<strong>de</strong> the purification of herpes-like <strong>virus</strong> of C. gigas and further <strong>de</strong>velopment of<br />

diagnosis melhods based on the use of nucleic acid probes or antibodies specifie for this <strong>virus</strong>, in or<strong>de</strong>r<br />

to study if it is possible to associate the <strong>de</strong>tection of nuclear abnormalilies to the presence of viral DNA<br />

and/or viral proteins. Establishment of such diagnosis methods wou Id enable not only to perform<br />

epi<strong>de</strong>miological study and survey of the disease, but also to verify hypothesis <strong>de</strong>veloped in this study.<br />

Literature cited<br />

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portugaise Crassostrea angu/ata Lmk. C. R. Hebd. Séanc. Acad. Sei., D, 283: 1595-1596.<br />

Comps M., Bonami J.R., Vago C. and Campillo A., 1976. Une virose <strong>de</strong> l'huître portugaise<br />

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angu/ata Th. C. R. Acad. Sei., D, 285: 1139-1 140.<br />

Comps M. and Cochennec N., 1993. A herpes-like <strong>virus</strong> from the European oyster Ostrea edu/is l. J.<br />

Invertebr. Pathol., 62(2) : 201 -203.<br />

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mollusks. Prog. Exp. Tumor Res., 20 : 283-294.<br />

Farley CA, 1978. Viruses and <strong>virus</strong>-like les ions in marine mollusks. Mar. Fish Rev., 40(10): 18-20.<br />

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Girard M. and Hirth l.,1989. Différents types d'interactions <strong>virus</strong>-cellule. In : Virologie moléculaire,<br />

chap. 5.1 : 199-207.<br />

109

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