Chemical Agents of Opportunity for Terrorism: TICs & TIMs

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Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide 51 Chemical Agents of Opportunity for Terrorism: TICs & TIMs Generating Phosphine Gas Module Four – Cyanide & Fumigants 51 Phosphides break down (on contact with water, oxygen, acid) to yield phosphine gas, the active pesticidal agent. Phosphine should not be confused with phosgene which is discussed in the Toxic Gases module. Aluminum phosphide is used as a rodenticide, insecticide and fumigant for stored cereal grains. It is used to kill small verminous mammals such as moles, rabbits, and rodents. Once wet, either in the environment or the GI tract of a rodent, phosphine is liberated. In some parts of the world, aluminum or zinc phosphide ingestion is a leading cause of suicide by overdose. December 2008 Version 2.0 Page 238
Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide 52 Chemical Agents of Opportunity for Terrorism: TICs & TIMs Clinical Phosphine : Treatment • Early/mild cases – Non-specific – GI effect, cough, chest tightness, eye irritation • Late/serious exposure – Pulmonary edema, coma, seizures, death – Knock-down gas • Rapid progression and deterioration in fatal cases Module Four – Cyanide & Fumigants 52 Shortly after exposure or following very low-dose exposure, patients will present with non-specific symptoms that may include GI effects (nausea, vomiting), cough, tightness of the chest, and eye irritation. If treatment is delayed or the exposure is heavier, subjects may experience pulmonary edema, coma, and seizure leading to death. Typically symptoms progress rapidly in cases of fatal exposure. December 2008 Version 2.0 Page 239
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