Chemical Agents of Opportunity for Terrorism: TICs & TIMs

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Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide 30 Chemical Agents of Opportunity for Terrorism: TICs & TIMs Seveso, Italy: The Aftermath • Zone A cleaned and soil removed • Thousands of soil and blood samples collected • Surveillance Programs – Liver enzyme induction, lipid metabolism, congenital malformation, immunosuppression , chloracne (193 cases) – 20 years later TCDD blood levels still high – Increased female:male birth ratio Module One - Terrorism by Fear and Uncertainty: Delayed Toxic Syndromes Despite the limited human toll acutely (chloracne in about 200 people), and even with intensive follow-up demonstrating minimally statistically significant changes in other health effects, the financial (and psychological) toll was severe. Extensive environmental testing (depicted in top picture) and millions of tons of soil were carted away in cylinders (bottom picture) and stored. 30 December 2008 Version 2.0 Page 338
Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide Chemical Agents of Opportunity for Terrorism: TICs & TIMs Unintentional Dioxin Release Controversial human effects • Many of the reported relationships between dioxin exposure and human toxicity have come under epidemiologic scrutiny • Carcinogenicity – Known carcinogen in mice and rats – In humans reported association with some cancers such as Non - Hodgkin ’s Lymphoma and soft tissue sarcomas but causation has not been established • Undisputed link between dioxin exposure and chloracne Module One - Terrorism by Fear and Uncertainty: Delayed Toxic Syndromes 31 The fear of carcinogenicity is the most important sociopolitical issue. However there is really no solid link of dioxins to human cancer despite its highly defined carcinogenicity in animal models. December 2008 Version 2.0 Page 339
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Chemical Agents of Opportunity for Terrorism: TICs & TIMs

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