Chemical Agents of Opportunity for Terrorism: TICs & TIMs

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Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide 16 Chemical Agents of Opportunity for Terrorism: TICs & TIMs Characteristics of Opioids Agent Potency (vs. morphine) Morphine 1 Meperidine 0.5 Methadone 4 Fentanyl 300 Sufentanil 4500 Alfentanil 75 Remifentani 220 lCarfentanil 10,000 Wax PM, Becker CE, Curry SC. Ann Emerg Med 2003;41:700 -5. Module Two - The Clinical Neurotoxicology of Chemical Terrorism 16 Fentanyl has a very high potency, which means it is effective in very small (microgram) doses. Carfentanil is even more potent and would make an effective weapon if put into a respirable form (e.g., aerosol). There are some suggestions that carfentanil was in fact the implicated toxin. This slide lists a number of chemicals or drugs which belong to the opioid class. They are all used medically except for carfentanil which is used as a veterinary anesthetic in large animals. The potency refers to how strong the drug is compared to another drug. The more potent a drug, the greater the effect at the same dose. A drug that has 10,000 times the potency of another drug is essentially 10,000 times stronger at the same dose. Hence, to produce a similar effect one would give a much, much smaller dose of the more potent drug. December 2008 Version 2.0 Page 84
Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide 17 Chemical Agents of Opportunity for Terrorism: TICs & TIMs Module Two - The Clinical Neurotoxicology of Chemical Terrorism 17 Carfentanil is available as a large animal tranquilizer (for Moose or elk) sold under the brand name of “Wildnil”. December 2008 Version 2.0 Page 85
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Chemical Agents of Opportunity for Terrorism: TICs & TIMs

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