Chemical Agents of Opportunity for Terrorism: TICs & TIMs

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Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide 26 In coma, enhancement of inhibition is the predominant cause of depressed mental status. In seizure/convulsion it is inhibition of inhibition that is most important. Remember that different neurotransmitters can either cause excitation (glutamate), or inhibition (GABA). Any change that tips the balance in favor of excitation can produce convulsions/seizures. This can occur by increasing excitatory neurotransmitters, or by decreasing the levels of inhibitory neurotransmitters. The most common toxin-induced seizures are triggered by decreasing the levels of inhibitory neurotransmitters. December 2008 Version 2.0 Page 94
Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide 27 Chemical Agents of Opportunity for Terrorism: TICs & TIMs Inhibition of inhibition Excitation Inhibition Module Two - The Clinical Neurotoxicology of Chemical Terrorism 27 This slide depicts the information stated on the previous slide. Decreasing or inhibiting the inhibition (smaller inhibition box) leads to increased excitation (larger excitation box). The scale is tipped in the excitation direction. December 2008 Version 2.0 Page 95
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Chemical Agents of Opportunity for Terrorism: TICs & TIMs

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