Chemical Agents of Opportunity for Terrorism: TICs & TIMs

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Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide 22 Chemical Agents of Opportunity for Terrorism: TICs & TIMs Methylmercury Poisoning Clinical Findings in Adults • Numbness around the mouth and in a stocking -glove distribution • Classic Triad – Ataxia - slight unsteadiness to inability to walk – Visual changes ranging from blurred or decreased vision to blind ness – Dysarthria - Slurring of speech • Mental deterioration • Severity of signs and symptoms are dose -dependent – Mild/moderate symptoms: 2.4 mg/kg – Severe symptoms: 3.6 mg/kg Module One - Terrorism by Fear and Uncertainty: Delayed Toxic Syndromes 22 The symptoms developed by Iraqi adults follow the typical progression for organic mercury poisoning. Initial numbness (paresthesias) around the mouth and distal extremities was followed by the triad of gait abnormalities, visual, and speech changes. Most toxins exhibit a dose-response relationship. Comparing clinical effects with estimates of methylmercury consumption from contaminated grain were consistent with a dose-response relationship. December 2008 Version 2.0 Page 330
Chemical Agents of Opportunity for Terrorism Training Support Package Participant Guide Slide 23 Chemical Agents of Opportunity for Terrorism: TICs & TIMs Methylmercury Poisoning Developmental Toxicity • Crosses placenta and accumulates in child • Transmitted mother to child via breast milk • Severe developmental delay / Cerebral - palsy-like syndrome • Mother may have minimal or no symptoms Module One - Terrorism by Fear and Uncertainty: Delayed Toxic Syndromes 23 The developing nervous system of the fetus and infant is particularly vulnerable to shortchain organic mercury compounds. . As a toxin that interferes with cellular, particularly neuronal, development, the presentations in neonates who had been exposed included severe developmental delays and cerebral palsy – like syndromes of incoordination and weakness/spasticity. December 2008 Version 2.0 Page 331
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Chemical Agents of Opportunity for Terrorism: TICs & TIMs

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