Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.1.7 Liver.
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Wu
1998
[41]
Taiwan
RCT
Consecutive pts with
elective liver resection.
90% malignant diagnoses.
Randomisation type not
given.
n=127
I: Cephazolin 1 g iv every 6 h
and gentamicin 80 mg every
8 h for 7 days beginning immediately
after operation (n=65)
C: No ab (n=62) Infective complications
defined as positive
culture from infected
side
I: 15 pts (23%)
C: 14 pts (23%)
Intraabdominal abscesses
I: 8 pts
C: 5 pts
High
Groups well matched.
Unique study. Clean
surgery but reticuloendothelial
system
reduced
ab = Antibiotics; C = Control group; h = Hours; I = Intervention group; n = Number
of patients; pts = Patients; RCT = Randomised controlled trial
Table 4.1.8 Pancreas.
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Schwartz
2001
[42]
Germany
RCT
Pts with pancreatic
cancer or chronic
pancreatitis. Major
surgery.
n=28
I: Ofloxacin 400 mg + metronidazole
0.5 g orally 2 h prior
to surgery (n=15)
C: Mezlocillin 4.5 g +
metronidazole 0.5 g iv
30 min before surgery
(n=13)
Post-op infection
defined by CDC
I: 1 pt
C: 2 pts
6% additional
antibiotics
Moderate
Both pancreatic
and colonic surgery
C = Control group; CDC = Centre for Disease Control; I = Intervention group;
iv = Intravenous; n = Number of patients; pts = Patients; RCT = Randomised controlled
trial
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