Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.4.2 continued
Author
Year
Reference
Country
Study design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Smaill
2002
[1]
Systematic
review
Meta-analysis
Women undergoing
elective and nonelective
caesarean
section, 81 RCT.
n=11 937
I: Antibiotics profylaxis C: No treatment
or
placebo
Fever
RR: All 0.45 (95% CI 0.39–0.52)
Elective: 0.49 (95% CI 0.32–0.75)
Non-elective: 0.40 (95% CI
0.31–0.51)
Wound infection
RR: All 0.41 (95% CI 0.35–0.48)
Elective: 0.73 (95% CI 0.53–0.99)
Non-elective: 0.36 (95% CI
0.26–0.51)
Moderate
Methodological
quality reasonably
good according
to authors
Endometritis
RR: All 0.39 (95% CI 0.34–0.43)
Elective: 0.38 (95% CI 0.22–0.64)
Non-elective: 0.39 (95% CI
0.34–0.46)
Urinary tract infection
RR: All 0.54 (95% CI 0.46–0.64)
Elective: 0.57 (95% CI 0.29–1.11)
Non-elective: 0.43 (95% CI
0.30–0.60)
Serious infectious morbidity/death
RR: All 0.42 (95% CI 0.28–0.65)
Elective: 1.01 (95% CI 0.04–24.21)
Non-elective: 0.28 (95% CI
0.13–0.61)
Side effects
13 studies/81 report side effects
I: Total events 17
C: Total events 13
C = Control group; CI = Confidence interval; I = Intervention group; IU = International
units; n = Number of patients; ns = Non significant; RCT = Randomised controlled trial;
RR = Relative risk
224 antibiotikaprofylax vid kirurgiska ingrepp KAPITEL 4 • den systematiska litteraturöversikten
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