Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.3.2 continued
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Pitt
1980
[3]
USA
RCT
Vascular surgical pts
with groin incision.
n=217
I1: Topical cephradine
in the wound prior to
closure (n=46)
I2: Cephradine 1 g 1 h
pre-op and x 3 every 6 h.
Total 4 doses (n=55)
I3: Both iv (as in I2)
and topical (as in I1)
(n=51)
C: No treatment
(n=53)
Wound infection
I1: 0%
I2: 0%
I3: 6% (3/51)
C: 25% (13/53)
12 pts
died within
4 weeks
Moderate
Majority of infections
occurred in the
groins and was caused
by Staphylococcus
aureus. It is not
stated if the trial was
placebo controlled.
Details of blinding are
not given. Included in
Steward 2007 [10]
Risberg
1995
[6]
Sweden
RCT
Vascular surgery
involving the groins.
n=580
Follow-up 30 days
I: Ciprofloxacin 750 mg x 2
post-op
C: Cefuroxime 1.5 g x
3 iv on day of surgery
Wound infection
I: 9.2%
C: 9.1%
112 (19.3%) Moderate
Multicenter. Double
blind. Results given
according to intention-to-treat
Stewart
2007
[10]
United
Kingdom
Systematic
review
Peripheral arterial
reconstruction
I1: Systemic ab iv
I2: Systemic ab iv >24 h
I3: Rifampicin-bonded grafts
C1: Placebo
C2: Placebo
C3: Ordinary grafts
Wound infection
Systemic ab iv vs
placebo (10 studies)
RR=0.25 (95% CI
0.17–38). Long course
ab vs short course ab
(3 studies) RR=1.28
(95% CI 0.82–1.98)
Graft infection Rifampicin-bonded
grafts
vs ordinary grafts
(3 studies) RR=0.63
(95% CI 0.27–1.49)
Not reported
High
Systematic review
of RCTs
The table continues on the next page
194 antibiotikaprofylax vid kirurgiska ingrepp KAPITEL 4 • den systematiska litteraturöversikten
195