Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.5.5 continued
Author
Year
Reference
Country
Study design
Population
characteristics
Intervention/
Method (I)
Control (C) Results Withdrawal
Drop outs
Study quality
and relevance
Comments
Knapp
1996
[48]
USA
RCT, quasirandomised,
open
Low-velocity gun shot
long bone fractures.
Excluded: Treatment
with other ab
Follow-up until
healed clinically
and radiologically
I: Cefapirin 2 g x 6 +
gentamicin 80 mg x 3
for 3 days (n=101,
120 fractures)
C: Ciprofloxacin
po 750 mg x 2
for 3 days (n=89,
102 fractures)
Wound infection
I: 2/118 fractures
(1.7%)
C: 2/100 fractures
(2%) ns
1 lost to
follow-up
(intervention
group).
3 excluded
for other ab.
I: 1, C: 2
Moderate
Inadequate randomisation.
Only gun shot
wounds, not representative
for other open
fractures
Patzakis
2000
[46]
USA
RCT, double
blind
Open fractures.
Excluded: Finger/toes,
renal impairment.
Stratified for severity
(I–III)
I: Ciprofloxacin iv
400 mg x 2 first day,
then 500 x 2 po. Duration
3 days with option
for 8 days in severe
cases (n=78)
C: Cefamandole
2 g x 4 iv + gentamicin
80 mg x 3.
Duration 3 days
with option for
8 days in severe
cases (n=93)
Wound infection
I: 11/78 (14.1%)
C: 6/93 (6.5%)
p=0.12
Wound infection rate
in Grade III fractures
I1: 8/26 (30.8%)
C: 2/26 (7.7%)
p=0.075
32 (29 lowvelocity
gun
shot wounds,
3 “protocol
violations”)
Moderate
Long and variable
duration of ab. Followup
not defined. 29 gun
shot injuries excluded
in retrospect. No power
calculation
Sloan
1987
[22]
United
Kingdom
RCT, open
Open distal finger
fractures