Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.2.2 continued
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Itani
2006
[18]
USA
RCT
Pts undergoing elective
colorectal surgery.
901 mITT (451/450)
and 672 (338/334) per
protocol.
Female/male: 52.7%/56.2%.
Age mean: 61.3 and
60.2 years.
n=1 002
Follow-up 4 weeks
I: Ertapenem 1 g 60 min
prior to the operation
(n=338)
C: Cefotetan 2 g
60 min prior to
the operation
(n=334)
SSI (superficial or deep
or organ-space infection)
Per protocol
I: 18.1%
C: 31.1%
Absolute difference –13.0%
(95% CI –19.5 to –6.5)
Any failure
I: 28%
C: 42.8%
Absolute difference –14.8%
(95% CI –21.9 to –7.5)
70 excluded
from randomisation.
No
ITT was performed
Moderate
Very high number
of failures in both
groups. In metaanalysis
[1]
Unexplained use of antibiotics
I: 6.9%
C: 7.5% ns
Anastomotic leakage
I: 3%
C: 4.2% ns
Distant site infections
I: 6 %
C: 6% ns
Ivarsson
1982
[24]
Sweden
RCT
Pts undergoing elective
colorectal surgery.
n=140
I: Cefoxitin 2 g 1–15 h
before operation and 2
more doses after 6 h and
12 h (n=55)
C: Doxycycline
200 mg before and
after 12 h (n=47)
Infectious complications
I: 18%
C: 13%
38 reason
given
Moderate
In meta-analysis
[1]
The table continues on the next page
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