Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.4.2 Caesarean section, antibiotic versus no antibiotics.
Author
Year
Reference
Country
Study design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Chelmow
2001
[2]
USA
Systematic review
Meta-analysis
Elective caesarean section
with intact membranes
I: Antibiotic prophylaxis
7 studies (n=219)
C: Placebo,
(n=227)
Postoperative fever
RR 0.25 (95% CI 0.14–0.44)
Endometritis
RR 0.05 (95% CI 0.01–0.38)
wound infection: 6.1% vs 10.3%,
RR 0.59 (95% CI 0.24–1.45)
Moderate
Generally
small studies
Rudge
2006
[8]
Brazil
RCT
Elective and non-elective
caesarean, low income
I1: Penicillin x 2 x II,
1 600 000 IU (n=200)
I2: Cephalotin x 1, 2 g
intraoperative (n=200)
C: No
antibiotics
(n=200)
Puerperal infection
I1: 2/200 (1%)
I2: 1/200 (0.55%)
C: 9/200 (4.5%)
I2 vs C: RR 0.11
(95% CI 0.013–0.973)
I1/I2 vs C: RR 0.176
(95% CI 0.038–0.724)
0 Moderate
Side effects:
not reported
Wound infection
I1: 7/200 (3.5%)
I2: 9/200 (4.5%)
C: 7/200 (3.5%) ns
The table continues on the next page
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