Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.13.3 Tonsillectomy.
Author
Year
Reference
Country
Study design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Dhiwakar
2008
[1]
Systematic
review
Meta-analysis
Cochrane
collaboration
9 RCT of patients
undergoing tonsillectomy
or
adenotonsillectomy
I: Any regimen of systemic antibiotic
prophylaxis administered
at or around the time of surgery
C: Placebo Total secondary
hemorrhage
I: n=22
C: n=25
RR 0.92
(95% CI 0.45
to 1.87), p=0.81
Significant hemorrhage
I: n=5
C: n=9
RR 0.49
(95% CI 0.08
to 3.11), p=0.45
Moderate
Weak methodology of the
included trials. Inadequate
allocation concealment,
5 RCT had adequate
double-blinding, intentionto-treat
analysis was possible
in 2 trials
Adverse events
or side effects
I: n=9
C: n=3
RR 2.06
(95% CI 0.68
to 6.27), p=0.13
Fever
I: n=31
C: n=46
RR 0.63
(95% CI 0.46
to 0.85), p=0.002
C = Control group; CI = Confidence interval; I = Intervention group; n = Number
of patients; RCT = Randomised controlled trial; RR = Relative risk
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