Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.1.11 Percutaneous endoscopic gastrostomy (PEG).
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results outcome 1
intervention
Withdrawal
Drop outs
Study quality
and relevance
Comments
Lipp
2006
[2]
Metaanalysis
(Cochrane
review)
Systemic ab to reduce
peristomal infection
in placement of percutaneous
endoscopic
gastrostomy. Out of
67 studies were 10
selected 1985–2005.
Power calculation.
Three studies blinded.
All ab given before
placement.
Follow-up 30 days
I: Cefuroxime 750 mg iv
30 min prior to PEG.
Ceftriaxone 1 g iv 30 min
prior to PEG.
Cefotaxime 2 g iv 30 min
prior to PEG.
Cefazolin 1 g iv 30 min
prior to PEG.
Cefoxitin 1 g iv 30 min
prior to PEG.
Piperacillin 2 g + 0.5 g
tazobactan.
Augmentin 1.2 g iv x 3,
first 30 min prior to PEG
(n=584)
C: Placebo or
no intervention
(n=516)
Infection
I: 51/584 (8%)
C: 135/516 (26%)
OR 0.31 (95% CI
0.22–0.44)
High
Prophylactic ab
should be routinely
administered
ab = Antibiotics; C = Control group; CI = Confidence interval; I = Intervention group;
iv = Intravenous; n = Number of patients;
132 antibiotikaprofylax vid kirurgiska ingrepp KAPITEL 4 • den systematiska litteraturöversikten
133