Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.4.5 Caesarean section, multiple doses vs single doses.
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Alekwe
2008
[79]
Nigeria
RCT Elective CS I: Single dose ceftriaxone 1 g iv,
after cord clamping (n=100)
C: Multiple dose of
ampiclox 1 g, gentamicin
80 mg and metronidazole
500 mg for 48 h, then
oral doses for another
5 days (n=100)
Endometritis
I: 14 (14%)
C: 15 (15%) ns
Wound infection
I: 7 (7%)
C: 8 (8%) ns
Total infection
rates 39% vs
44%, ns
Moderate
Hopkins
1999
[3]
Systematic
review
Metaanalysis
CS, elective
and non-elective,
51 trials.
n=10 096
6 comparisons:
I1: Ampicillin vs cephalosporin
1st generation
I2: Ampicillin vs 2nd/3rd
generation cephalosporin
I3: 1st generation cephalosporin
vs 2nd/3rd generation
I4: Multiple dose antibiotics
vs single dose
I5: Systemic vs lavage admission
I6: Timing, early vs late
admission
Endometritis
I1: No sign difference,
OR 1.27 (95% CI
0.84–1.93)
I2: No sign difference,
OR 0.83 (95% CI
0.54–1.26)
I3: No sign difference,
OR 1.21 (95% CI
0.97–1.51)
High
Study quality
overall excellent
according
to authors
I4: No sign difference,
OR 0.92 (95% CI
0.70–1.23)
I5: No sign difference,
OR 1.19 (95% CI
0.81–1.73)
I6: Insufficient evidence
CI = Confidence interval; CS = Caesarean section; I = Intervention group; n = Number
of patients; ns = Non significant; RCT = Randomised controlled trial
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