Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.5.3 Closed fractures; duration of prophylaxis and comparison
of different antibiotics.
Author
Year
Reference
Country
Study design
Population
characteristics
Intervention/
Method (I)
Control (C) Results Withdrawal
Drop outs
Study quality
and relevance
Comments
Buckley
1990
[10]
Canada
RCT double
blind. Included
power calculation
Hip fracture surgery.
Excluded: Pre-op ab
for >7 days
I: Cefazolin
2 g at induction
of anesthesia
+
placebo
x 3 x I (n=83)
C: Cefazolin 2 g at
induction of anesthesia
+ 2 g x 3 x I (n=121)
Deep wound infection
I: 0/83
C: 0/121
ns
Superficial wound
infection
I: 2/121 (1.6%)
C: 2/83 (2.4%)
ns
40/352 High
Included in
Cochrane review
[5]. Low event rate
Garcia
1991
[11]
Spain
RCT single blind.
Includes power calculation
Closed fractures operation
with metal devices.
Excluded: Total hip replacement,
infection in area.
Follow-up “on demand”
I1: Cefonicid
(t1/2=4.5 h)
2 g one dose
at induction
of anesthesia
(n=474)
I2: Cefamandole
2 g
(t1/2=48 min)
at induction
of anesthesia,
2 h and 8 h
after (3 doses)
(n=510)
I3: Cefamandole
at
induction of
anesthesia,
2 h, 8 h, 14 h,
24 h after
(5 doses)
(n=505)
Wound infection
(deep and superficial)
I1: 7/474 (1.5%)
I2: 10/510 (2%)
I3: 10/505 (2%)
ns
Drop outs or lost
to follow-up not
mentioned
High
Included in
Cochrane review
[5]. Follow-up
unclear
The table continues on the next page
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