Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.2.2 continued
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Song
1998
Cont 3
[2]
Systematic
review
Other comparisons
Surgical wound infection
(abdominal wound infection)
Metronidazole alone vs
metronidazole + other
antibiotics 17% vs 6%
OR 3.19 (95% CI 1.41–7.23)
Combination therapy
more effective vs piperacillin
OR=0.57 (95% CI
0.38–0.85), doxycyclline
OR=0.19 (95% CI 0.07–0.52;
cefotaxime OR=0.5 (95%
CI 0.31–0.81); tinidazole
OR=0.27 (95% CI 0.09–0.84),
gentamicin OR=0.10 (95%
CI 0.02–0.1). Combination
not better than gentamicin
+ metronidazole, cefalosporines
Song
1998
Cont 4
[2]
Systematic
review
I9: 1st generation
cephalosporin
C9: 2nd and
3rd generation
cephalosporin
Surgical wound infection
(abdominal wound infection)
No difference OR=1.07
(95% CI 0.58–2.12)
Song
1998
Cont 5
[2]
Systematic
review
70 different antibiotics or
combination of antibiotics
had been assessed. Focus
on newer cephalosporins
and single vs multiple
doses
Adverse events
Skin rash and diarrhoea was
commonly reported. 42 trials
reported mortality ranging
from 0–16% with average of
4%. Could be biased since
probably many of the trials
that did not report mortality
would have 0% in mortality
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