Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.3.2 continued
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Vardakas
2005
[11]
Greece
USA
Metaanalysis
6 randomised controlled
trials. Orthopedic and
vascular surgery with
prosthetic material.
n=2 886, 510 V
I: Teicoplanin C: 1st and 2nd
generation
cephalosporins
Infection rate
No signicant
difference. OR 1.32
(95% CI 0.45–3.84)
High
The 2 therapies were
equally effective
Worning
1986
[4]
Denmark
RCT
Peripheral vascular
surgery.
n=115
I: Methicillin 2 g + netilcilin
200 mg. First dose at anesthesia.
Second and third
at 8 and 16 h, respectively
(n=69)
C: Placebo (n=72) Wound infection
Grade I–III
I: 4/69 (5.8%)
C: 12/72 (16.7%)
p=0.04
Postoperative
complications
ns
14 pts, the
reasons are
specified
High
An early placebo
controlled trial.
Shows the necessity
of prophylaxis
ab = Antibiotics; C = Control group; h = Hour; I = Intervention group; iv = Intravenous;
n = Number of patients; ns = Non significant; pts = Patients; RCT = Randomised controlled
trial
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