Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.1.4 continued
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
indiviuduals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Tocchi
2000
[36]
Italy
RCT
Elective laparoscopic
cholecystectomy.
Multivariate analysis
of risk factors. Observer
blinded. SSI defined.
Follow-up 4 weeks
I: 30 min before anesthesia
and at 24 h 2 g cefotaxime
(n=44)
C: Isotonic saline
at same timepoints
(n=40)
Post-op infection rate
I: 3 wound infections,
1 UTI, 1 subhepatic
abscess
Overall infection rate
11.3%
C: 4 wound infections,
1 bronchopneumonia,
2 UTI
Overall 15.5%
6 pts Moderate
Risk factors: Biliary colic
within 30 days prior to
operation or DM. Age
no risk factor
ab = Antibiotics; ASA = Acetylsalysylic acid; C = Control group; CDC = Centers for
disease control; CI = Confidence interval; CT = Controlled trial; DB = Double blind;
DM = Diabetes mellitus; I = Intervention group; iv = Intravenous; LC = Laparoscopic
cholecystectomy; n = Number of patients; NNT = Number needed to treat; NS =
Non significant; OC = Open cholecystectomy; OR = Odds ratio; Pts = Patients;
q = Every; RCT = Randomised controlled trial; RTI = Respiratory tract infection;
SSI = Surgical site infection; UTI = Urinary tract infection
106 antibiotikaprofylax vid kirurgiska ingrepp KAPITEL 4 • den systematiska litteraturöversikten
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