Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.12.8 Extracorporeal Shockwave Lithotripsy (ESWL).
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Bierkens
1997
[43]
The Netherlands
RCT
ESWL. Sterile urine
pre-treatment
Follow-up 2 and
6 weeks
I1: Single dose ciprofloxacin
200 mg iv (n=41)
I2: Single dose cefuroxime
750 mg iv (n=39)
I3: Ciprofloxacin 200 mg iv day 1
+ 250 mg oral bid day 2–7 (n=29)
I4: Cefuroxime 750 mg day 1 +
250 mg oral day 2–7 (n=38)
C: Placebo
(n=30)
BU >10 000 cfu/mL
2 weeks
I1: 6/41 (16%)
I2: 8/39 (21%)
I3: 4/29 (14%)
I4: 11/38 (29%)
C: 5/30 (17%)
6 weeks
I1: 8/39 (20%)
I2: 8/33 (24%)
I3: 10/33 (30%)
I4: 9/38 (24%)
C: 7/37 (19%)
Symptomatic UTI
2 weeks
I1: 2/41
I2: 1/39
I3: 0/29
I4: 0/38
C: 1/30
6 weeks
I1: 1/39
I2: 0/33
I3: 1/33
I4: 0/38
C: 1/37
22% High
Overall BU 20%
of wich 58% had
symptoms but
≤3% symptomatic
UTI. No significant
reduction by ABP.
No difference
in presence of
indwelling catheter.
Study ended after
interim analysis
showing no difference
Claes
1989
[44]
Belgium
RCT
Pre-ESWL sterile
urine pre-treatment
culture. No risk
factors (staghorn
stone, stents,
recurrent UTI).
n=181
Follow-up 1 day
I: ingle dose amoxycillin/
clavulanate 2 g/0.2 g iv
(n=89)
C: No ab
(n=92)
BU
I: 0/92
C: 7/89
Fever
I: 1/92
C: 16/89
BU + clinical signs
I: 0%
C: 7.6%
5% High
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