Antibiotikaprofylax vid kirurgiska ingrepp - SBU

Table 4.8.2 continued
Author
Year
Reference
Country
Study
design
Population
characteristics
Intervention
Method
Number individuals
Control
Number
individuals
Results
Withdrawal
Drop outs
Study quality
and relevance
Comments
Kreter
1992
[1]
Canada
Metaanalysis
Cardio-thoracic
operations
Total 28 studies,
6 759 patients;
prospective design,
randomised
4 placebo-controlled
studies.
n=405
I: Antibiotic. Antistaphylococcal
pencillin or 1st generation of
cephalosporin
C: Placebo Total SSI stenal wound
+ sapenous vein donor
site infection
I: Ranged from 0–6.7%
C: Ranged from 9.1–54.5%
OR 4.96 (95% CI
2.06–9.72)
Corresponds to an
approximate reduction
in wound infections rate
from 20–25% in placebo
to 4–5% in antibiotic
treated
Leg wound infection
I: Few CABG procedures
C: Few CABG procedurs
Moderate
Authors own conclusions;
Limitations;
lack of power, stratification
of pts according
to emergency
or type of procedure
lacking, variations in
definitions of outcome
(infection), removal
from consideration
after randomisation
varied 0–31%, doses
of antibiotics used
were justified by
pharmacokinetic
studies in some
cases, but seemed
unusually low in
others
C = Control group; CABG = Coronary artery bypass graft; ECC = Extracorporeal
circulation; CI = Confidence interval; I = Intervention group; im = Intramuscular; iv =
Intravenous; ns = Non significant; OR = Odds ratio; pts = Patients; RCT = Randomised
controlled trial; SSI = Surgical site infection
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