2011 年底结题项目汇编 - 国家自然科学基金委员会医学科学部

医 学 科 学 部 六 处 重 点 项 目 H2401 地 方 病 学 8Xiaorong Zhou, Bruce Caterson, Clare Hughes. Histopathology of Chondronecrosis development inknee articular cartilage in a rat model of Kashin-Beck disease using T-2 toxin and Selenium deficiencyconditions. RHEUMATOL INT. 2011. accepted. (IF: 1.431)[8] Farooq Umer, GUO X, Chuang LH, Fang H, Zhuang GH, Xia CT. Measuring health-related quality oflife in Kashin-Beck disease using EQ-5D. Qual Life Res. 2011. 20(3): 425-429. (IF:1.958)[9] Jian Sun, Qingzhu Sun, Shemin Lu. From selenoprotein to endochondral ossification: A novelmechanism with microRNAs potential in bone related diseases? Med Hypotheses. 2011. 77(5):807-11(IF:1.389)[10] Tian L, Wang W, Hou W, Tian J, Zhong N, Sun J, Guo D, Yao J, Xu P, Su P, He L, Lu S. The differentautoimmune and inflammatory responses in Kashin-Beck Disease in comparison with rheumatoidarthritis and osteoarthritis. Hum Immunol. 2011. 72(10):812-816. (IF:2.872)[11] Dongmin Li, Xuan Wang, Wuchao Ren, Rikard Holmdahl, Shemin Lu. High Expression of LiverHistone Deacetylase 3 Deteriorates High-fat-diet-induced Metabolic Syndrome Through Suppressingthe Pathway of PPAR-γ and LXR-α in E3 Rats. Mol Cell Endocrinol. 2011. 344(1-2):69-80.(IF:4.119)[12] Zhu W, Meng L, Jiang C, Hou W, Xu J, Wang B, Lu S. Induction of toll-like receptor 2 positiveantigen-presenting cells in spleen of pristane-induced arthritis in rats. Mol Biol Rep. 2011.Epub.(IF:1.875)[13] Zhu W, Meng L, Jiang C, He X, Hou W, Xu P, Du H, Holmdahl R, Lu S. Arthritis is associated withT-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther. 2011.13(3): R103. (IF:4.357)[14] Qingzhu Sun, Xudong Yang, Raza Asim M B, Fangfang Jiao, Xiaojing He, Dongmin Li, Shemin Lu.Different challenge terms determine disease patterns of antigen-induced pulmonary inflammation inE3 rats. AMPIS. 2011. 119: 229-238. (IF:1.944)[15] Liesu Meng, Xiaojing He, Wenhua Zhu, Xudong Yang, Congshan Jiang, Qingzhu Sun, Asim RazaM.B., Simeng Zhang, Qian Xue, Xinfang Xie, Shemin Lu. TLR3 and TLR7 modulate IgE productionin antigen induced pulmonary inflammation via influencing IL-4 expression in immune organs. PLoSONE. 2011. 6(2): e17252. (IF:4.411)[16] Liu SZ, Tian LF, Xu P, Zhuang GH, Zheng F, Tian J, Ning QL, Zhu BF, Lu SM, Yan H. Analysis ofcorrelation between blood biochemical indicators and bone mineral density of post-menopausalwomen. Mol Biol Rep. 2011. 38(2): 939-948. (IF: 1.875)[17] Hou WK, Meng LS, Zheng F, Wen YR, Zhu WH, Jiang CS, He XJ, Zhou Y, Lu SM. Methotrexateameliorates pristane-induced arthritis by decreasing IFN-gamma and IL-17A expressions . JZHEJIANG UNIV SCI B. 2011. 12(1): 40-46. (IF: 1.027)[18] Jing-hong Chen, Chu Y, Cao J, Wang W, Liu J, Wang J. Effects of T-2 toxin and selenium onchondrocyte expression of matrix metalloproteinases (MMP-1, MMP-13), α2-macroglobulin (α2M)and TIMPs. Toxicol In Vitro. 2011. 25(2):492-499. (IF: 2.546)[19] Jing-hong Chen, Senghai Xue, Siyuan Li, Zhi-lun Wang, Haojie Yang, Wei Wang, Daiqing Song,Xiaorong Zhou, Chen Chen. Oxidant Damage in Kashin-Beck disease and a rat Kashin-Beck diseasemodel by employing T-2 toxin treatment under selenium deficient conditions. J Orthop Res. 2011.accepted. (IF: 2.976)[20] Liu JT, Guo X, Ma WJ, Zhang YG, Xu P, Yao JF, Bai YD. Mitochondrial function is altered in articularchondrocytes of an endemic osteoarthritis, KashineBeck disease. Osteoarthritis Cartilage. 2010. 18(9):NSFC 医 学 科 学 部 六 处 预 防 医 学 学 科2011 年 底 结 题 项 目 汇 编