Programmreport 2012 - DORIS - Bundesamt für Strahlenschutz

workers of the Wismut AG (3610S40007)“ conducted as case-control-study embedded in the Wismut-cohort
relevant data had to be collected for about 600 persons. Informations of special interest are medical
chest-x-rays due to routinely conducted examinations among uranium miners. Data collection comprised
15 581 datasets on 640 persons.
SUBJECT AREA 02 - RADIATION PROTECTION TECHNIQUES
Phantoms are widely used within QC procedures of diagnostic X-ray equipment. Up to now no vendor-independent
QA system for phantoms is established. Within the frame of the project “Development of procedures
to determine the conformance of phantoms, used for quality assurance in radiography, with
their specification in corresponding standards (3608S20001)“ non destructive test procedures were
developed. Using these procedures it is possible to check the norm conformance of phantoms with adequate
uncertainty. The test procedures have been used on a control sample from phantoms which are in clinical usage.
Within these tests for an increased number of phantoms qualitative and quantitative faults have been
found. It is to be assumed that in several cases the deviations within the phantoms have clear influence on
the outcome of the tests.
Active electronic personal dosemeters (EPD) are broadly used within personal dosimetry. Since some time it
is known that the response of EPDs is dose rate dependent. At doses, which are too high for the EPD signal
detection chain the response drops. The intention of the project “Dosimetry in pulsed X-ray fields using
active electronic dosemeters (3610S20001)“ was to prove the usability of EPD for personal dosimetry
within radiation diagnostics in human and veterinary medicine.
The dose rate dependence of EPD of the device types Mk 2.3 and DMC2000X have been studied under laboratory
conditions. It was found that at dose rates below about 1 Sv/h 1) the response of the EPDs was above
80%, which was found suitable for their purpose.
The maximum dose rate at all work places as well as whereabouts of assisting persons in human and veterinary
medicine was estimated. The conservatism of the estimation was checked by measurements. In all but
one cases the dose rate was clearly below 1 Sv/h. Thus, it is to be assumed that EPDs are fit for use in all
working places in human and veterinary medicine.
SUBJECT AREA 03 - RADIATION BIOLOGY - EFFECTS OF IONISING RADIATION, RADIOSENSITIVITY
The organisers of the project “2nd Radiation Proteomics Workshop (3612S30032)“ on 30-31 January 2013
in Neuherberg/Munich aimed to encourage the discussion between radiation biologists and proteomics specialists
regarding new methods, challenges, state of the art and future co-operation in the field of radiation
proteomics. During the intensive two days with lectures, posters, and information about the latest methodological
highlights and challenges in proteomics, the status of radiation proteomics today was outlined and future
goals speeding up the process of discovery of new molecular targets of ionising radiation were set. The focus
of the discussions was: how could proteom analyses contribute to the issues individual radiation sensitivity,
system effects of ionising radiation, biological effects of low dose and low dose rates and radiation effects on
epigenetic mechanisms? In contrast to effects of high doses the health effects of low doses are still insufficiently
explored. The investigation of the whole proteom with high throughput analyses could therefore provide
new information about signaling pathways and mechanisms triggered by low dose ionising radiation in cells
and organs. The workshop was organised by Helmholtz Center Munich and the Federal Office for Radiation
Protection.
SUBJECT AREA 04 - MEDICAL RADIATION EXPOSURES / X-RAY ORDINANCE
In the first subproject of the research project “Physical optimisation and risk assessment of diagnostic
and therapeutic procedures using ionising or non-ionising radiation (3608S04001)“ three functional imaging
techniques were implemented and carefully optimised and validated for biologically-adapted radiotherapy
using phantom experiments, namely (1.) H-1-Chemical-Shift-Imaging (H-1-CSI) at a 3-T-MRI system, (2.)
dynamic positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) in combination with (3.)
dynamic contrast enhanced (DCE) CT at a modern hybrid PET/CT system. Due to the low spatial resolution
1) The unit sievert per hour (Sv/h) is used to specify the measuring range of dosemeters. Pulsed fields apparently
give rise to very high dose rates (in a range of several Sv/h). However, radiation exposure in fact occurs only
during the short length of pulses which is in a range of milli- or microseconds
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