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Evolution__3rd_Edition

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Study and review questions<br />

1 Here are the haplotype frequencies in four populations.<br />

CHAPTER 8 / Two-locus and Multilocus Population Genetics 221<br />

Genotype<br />

Population A 1 B 1 /A 1 B 1 A 1 B 1 /A 1 B 2 A 1 B 2 /A 1 B 2 A 1 B 1 /A 2 B 1 A 1 B 1 /A 2 B 2 A 1 B 2 /A 2 B 2 A 2 B 1 /A 2 B 1 A 2 B 1 /A 2 B 2 A 2 B 2 /A 2 B 2<br />

1 3/16 1/16 0 1/16 3/8 1/16 0 1/16 3/16<br />

2 1/16 1/8 1/16 1/8 1/4 1/8 1/16 1/8 1/16<br />

3 1/81 4/81 4/81 4/81 16/81 16/81 4/81 16/81 16/81<br />

4 0 1/81 8/81 2/81 8/81 26/81 7/81 27/81 2/81<br />

Calculate the linkage disequilibrium in each.<br />

Frequency of<br />

Population A 1 B 1 A 1 B 1 Value of D<br />

1<br />

2<br />

3<br />

4<br />

2 What kinds of selection can be hypothesized to be<br />

operating in populations 1–4 of question 1?<br />

3 In a large population, with random mating, and in the<br />

absence of selection, what haplotype frequencies would<br />

you expect in populations 1–4 of question 1 after a few<br />

hundred generations?<br />

4 Distinguish three explanations for a local reduction in<br />

genetic diversity within the DNA of a species. How can<br />

you test between them?<br />

5 Draw a fitness surface for a single locus with two<br />

alleles (A and a) and heterozygous advantage. Where is<br />

the equilibrium on the graph?

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