QF0159 Marketing Release Record
QF0159 Marketing Release Record
QF0159 Marketing Release Record
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Novocastra P-selectin (CD62P)<br />
Clone C34<br />
1 mL lyophilized NCL-CD62P-367 P (HIER)<br />
The CD62P antigen (140 kD), also known as P-selectin, mediates the<br />
interaction of activated platelets with neutrophils and monocytes and is<br />
responsible for the rolling attachment of neutrophils to activated<br />
endothelium. CD62P antigen binds to the carbohydrate structures Sialyl-<br />
Lewis x on neutrophils and to galactosyl ceramides on neutrophils and tumor<br />
cells. A soluble CD62P antigen inhibits the integrin-mediated adhesion of<br />
activated neutrophils to endothelium.<br />
Human umbilical cord, blood vessel: immunohistochemical staining for CD62P antigen<br />
(P-selectin) using NCL-CD62P-367. Note intense staining of platelets. Paraffin section.<br />
Novocastra Renal Cell Carcinoma<br />
Marker<br />
Clone 66.4.C2 Reference Range<br />
1 mL, 0.1 mL lyophilized NCL-RCC P (Enzyme)<br />
Antigen Background<br />
RUO*<br />
In the normal kidney, a 200 kD glycoprotein is localized within the brush<br />
border of the pars convoluta and pars recta segments of the proximal renal<br />
tubule and on the luminal surface of Bowman's capsule adjoining the<br />
outgoing proximal tubule. The glycoprotein, gp200, is also reported to be<br />
expressed on the luminal surface of breast lobules and ducts, the luminal<br />
surface of the epididymal tubular epithelium and within the colloid of thyroid<br />
follicles. Reports indicate gp200 antigen to be expressed in approximately<br />
93 percent of primary and 84 percent of metastatic renal cell carcinomas.<br />
Product Specific Information<br />
NCL-RCC is specific for a proximal nephrogenic renal antigenic site on the<br />
carbohydrate domain of gp200.<br />
Human renal cell carcinoma: immunohistochemical staining for gp200 using NCL-RCC. Note<br />
cytoplasmic staining of tumor cells. Paraffin section. Section supplied courtesy of Dr Mouza<br />
Abdulla A. Al-Sharhan.<br />
IVD<br />
Novocastra Respiratory syncytial virus<br />
Clone 5H5N, G12 2 , 5A6, IC3 cocktail<br />
1 mL lyophilized NCL-RSV3 F P (HIER) I<br />
RUO*<br />
Respiratory syncytial virus (RSV) is the most important respiratory pathogen<br />
of childhood and is responsible for approximately 50 percent of all cases of<br />
bronchiolitis and 25 percent of all cases of pneumonia during the first few<br />
months of life. Approximately one percent of babies who develop an RSV<br />
infection between two and six months die, particularly those with congenital<br />
heart defects, bronchopulmonary dysplasia, low birth weight or<br />
immunodeficiency. The virus is also associated with significant lower<br />
respiratory disease in elderly and immunosuppressed individuals in whom<br />
mortality rates may be high. Multiple types and subtypes of RSV cocirculate<br />
in the population.<br />
Product Specific Information<br />
NCL-RSV3 is a cocktail of four antibodies. NCL-RSV3 does not cross-react<br />
with Parainfluenza virus types 1, 2, 3 and 4b, Adenovirus, Mumps virus,<br />
Measles virus, Influenza virus types A and B, Poliovirus types 1, 2 and 3,<br />
Coxsackie B4 virus, echovirus 19, Varicella-zoster virus, Cytomegalovirus and<br />
Herpes simplex virus types 1 and 2.<br />
Human infant lung, post-mortem tissue: immunohistochemical staining for Respiratory<br />
syncytial virus (RSV) using NCL-RSV3. Note intense staining of infected luminal bronchial<br />
epithelial cells. Paraffin section.<br />
Novocastra Retinoblastoma Gene<br />
Protein<br />
Clone 13A10<br />
1 mL, 0.1 mL lyophilized NCL-RB-358 F P (HIER) W<br />
1 mL liquid NCL-L-RB-358 F P (HIER) W RUO*<br />
RUO*<br />
Clone 1F8<br />
1 mL lyophilized NCL-RB F P (HIER) W RUO*<br />
Clone 13A10 was developed to produce superior staining on paraffin<br />
sections.<br />
Retinoblastoma (Rb) is a rare tumor of the retina associated with mutations<br />
of chromosome 13. The nuclear phosphoprotein encoded by the Rb tumor<br />
suppressor gene is present in many cells and may indirectly regulate cell<br />
growth by activating the transcription factor ATF-2. Activation of ATF-2<br />
initiates expression of TGF-beta2, which in turn inhibits transcription of<br />
genes affecting cell growth. Bilateral mutation of the Rb gene may<br />
potentially play a role in the development of a number of malignant tumors.<br />
Product Specific Information<br />
NCL-RB-358 was raised to the N-terminal region of the Rb gene protein.<br />
F Frozen I Immunofluorescence E Electron microscopy<br />
P Paraffin C Flow cytometry O Other applications<br />
W Western blotting<br />
/99<br />
Primary Antibodies