QF0159 Marketing Release Record

Normal human cervix: immunohistochemical staining for p72 protein using NCL-p73.
Note nuclear staining of basal epithelial cells.
Novocastra p80 (Anaplastic Lymphoma
Kinase)
(ALK) (CD246)
Clone 5A4
1 mL, 0.1 mL lyophilized NCL-ALK P (HIER)
7 mL BOND ready-to-use PA0306 P (HIER)
See also ALK (Anaplastic Lymphoma Kinase) (CD246) (p80) on page 20.
Novocastra Papillomavirus Antibodies
Clone 5A3
2 mL, 0.1 mL lyophilized Papillomavirus (type 18)
NCL-HPV18 F P (HIER) RUO*
Clone 4C4
2 mL, 0.1 mL lyophilized Papillomavirus (types 6, 11,18)
NCL-HPV-4C4 F P (HIER) RUO*
Antigen Background
Infection with specific types of human Papillomavirus (HPV) has been
associated with an increased risk of developing cervical neoplasia. HPV
types 6 and 11 have been associated with relatively benign diseases such as
genital warts but types 16 and 18 are the causative agents of cervical, vaginal
and vulvar malignancies.
Product Specific Information
NCL-HPV18 is specific for the L1 coat protein of HPV type 18. NCL-HPV-4C4 is
specific for HPV types 6, 11 and 18.
IVD
IVD
Novocastra Parathyroid Hormone
Clone 105G7
1 mL lyophilized NCL-PTH-488 P
Antigen Background
The parathyroid glands are small, oval, endocrine glands closely associated
with the thyroid gland. The parathyroid glands regulate serum calcium and
phosphate levels via parathyroid hormone (parathormone). Parathyroid
hormone raises serum calcium levels directly, by increasing the rate of
osteoclastic reabsorption and promoting breakdown of the bone matrix, and
indirectly, by increasing the renal tubular reabsorption of calcium ions and
inhibiting the reabsorption of phosphate ions from the glomerular filtrate, and
finally, by promoting the absorption of calcium from the small intestine.
Parathyroid hormone is the most important regulator of blood calcium levels
and is essential to life, whereas calcitonin appears only to provide a
complementary mechanism for fine adjustment. Chief cells are the most
abundant cells in the parathyroid gland and are responsible for the secretion
of parathyroid hormone. Antibodies to parathyroid hormone together with
antibodies to thyroglobulin are useful in studies to differentiate parathyroidderived
lesions from thyroid-derived lesions.
Human parathyroid: immunohistochemical staining for parathyroid hormone using NCL-PTH-
488. Note cytoplasmic staining of chief cells. Paraffin section.
Novocastra Parvalbumin (Alpha)
Clone 2E11
1 mL lyophilized NCL-PARVALBUMIN P (HIER)
Alpha and beta parvalbumins are low molecular weight, water-soluble,
calcium-binding proteins. The protein is found in a subset of fast-spiking
inhibitory GABAergic interneurons with a Ca 2+ buffering capacity that
reduces the Ca 2+ -dependent K + outward current. Unlike other Ca 2+ binding
proteins, parvalbumin-containing neurons appear to co-localize only with
corticotropin-releasing factor and not with other neuropeptides associated
with GABA such as somatostatin, neuropeptide Y and cholecystokinin.
Neurons which contain parvalbumin appear to be resistant to ischemia,
epilepsy and N-methyl-D-aspartate receptor agonists due to their ability to
buffer increase in intracellular calcium. Alpha and beta parvalbumins are
reported to be expressed in different human tissues with the alpha form
highly expressed in extracts of human cerebellum, weakly in kidney and not
in skeletal muscle, thymus, lung, placenta, heart, liver and diaphragm. The
beta form of parvalbumin has been detected only in preterm placenta. These
expression patterns differ significantly between human and rodent species
with these differences also reflected with some members of the S-100 family
of Ca 2+ binding proteins. Within the cerebellum, alpha parvalbumin is
reported to be localized to Purkinje, basket, stellate and Golgi cells. In cases
of spinocerebellar ataxia-1 (SCA-1), the number of Purkinje cells expressing
alpha parvalbumin is reported to be much reduced, which may reflect
biochemical changes preceding Purkinje degeneration.
Product Specific Information
NCL-PARVALBUMIN does not detect parvalbumin in preterm placenta
indicating its specificity for the alpha form of this protein.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
IVD
RUO*
/93
Primary Antibodies