QF0159 Marketing Release Record

Primary Antibodies
Normal human colon: immunohistochemical staining for Sialyl Lewis a antigen using
NCL-L-CA19-9. Note extracellular-associated staining of colonic epithelial cells. Paraffin
section.
Novocastra CA125 (Ovarian Cancer
Antigen)
Clone Ov185:1
1 mL lyophilized NCL-CA125 F P (HIER)
1 mL liquid NCL-L-CA125 F P (HIER)
7 mL ready-to-use RTU-CA125 F P (HIER)
7 mL BOND ready-to-use PA0539 P (HIER)
Antigen Background
CA125 antigen is usually associated with ovarian epithelial malignancies.
Serum assays are widely used to detect this protein in the monitoring of
ovarian cancers. CA125 antigen may also be detected by immunohistochemistry
and expression has been found in neoplasms such as seminal
vesicle carcinoma and anaplastic lymphoma. CA125 antigen is not found
exclusively in malignant tumors. CA125 is also known as MUC16.
Papillary carcinoma of endometrium: immunohistochemical staining for ovarian cancer
antigen using NCL-L-CA125. Note staining of the luminal surface of malignant endometrial
cells. Paraffin section.
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Novocastra Calbindin
Clone KR6
1 mL lyophilized NCL-CALBINDIN P (HIER)
Calbindin is a calcium-binding protein belonging to the troponin C
superfamily. It functions as a buffer of cytosolic calcium and is found in the
brain, kidney, gut and pancreatic islets. In normal brain, calbindin (28 kD)
has been identified in medium sized neurons of the neuropil of the matrix
compartment of the striatum, the woolly fiber arrangements of the globus
pallidus and the fiber structures of the pars reticula of the substantia nigra.
The normal expression of calbindin is modified in patients with progressive
supranuclear palsy, striatal degeneration and Huntingdon's disease (HD). In
HD, alterations to the dendritic arbors and spiny striatal neurons may be
visualized by immunohistochemistry for calbindin. In moderate grades of HD,
proliferative changes have been found in these areas and in severe grades,
degenerative changes have been noted. A proportion of dendritic cells
within the light zone of germinal centers are also noted to be positive for
calbindin.
Human brain, cerebellum: immunohistochemical staining for calbindin using NCL-CALBINDIN.
Note cytoplasmic staining of Purkinje cells and neuronal processes. Paraffin section.
Novocastra Calcitonin
Clone CL1948
1 mL, 0.1 mL liquid NCL-L-CALCITONIN P (Enzyme)
Polyclonal
7 mL BOND ready-to-use PA0406 P (Enzyme) IVD
Antigen Background
Calcitonin (CT) is a 32 amino acid peptide synthesized by the parafollicular C
cells of the thyroid. It acts through its receptors to inhibit osteoclast mediated
bone resorption, decrease calcium resorption by the kidney and decrease
calcium absorption by the intestines. The action of calcitonin is therefore to
cause a reduction in serum calcium, an effect opposite to that of parathyroid
hormone. The calcitonin gene transcript also encodes the calcitonin generelated
peptide (CGRP), which is thought to be a potent vasodilator. The tissue
specificity of the transcript produced depends on alternative splicing of the
CT/CGRP gene transcript. In the parafollicular cells of the thyroid 95 percent
of the CT/CGRP is processed and translated to produce CT, however, in
neuronal cells 99 percent of the CT/CGRP RNA is translated into CGRP. The C
cells of the thyroid give rise to an endocrine tumor, medullary thyroid
carcinoma (MTC), which occurs in a sporadic (75 percent of cases) and
hereditary form (25 percent of cases). Familial MTC is associated with C cell
hyperplasia (CCH), whereas sporadic MTC is thought not to be. However, in
the general population CCH is present in 20-30 percent of thyroid glands,
either with normal histology, thyroiditis or follicular tumors.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.
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