QF0159 Marketing Release Record

Origin
Desmin
Clone DE-R-11
50 Tests ORG-8889
Antigen Background
Human desmin is a 53 kD cytoplasmic intermediate filament protein in striated
and smooth muscle cells. It is confined to the Z bands in skeletal and cardiac
muscle giving a characteristic striated appearance when
immunohistochemically stained.
Product Specific Information
Origin Desmin (Clone DE-R-11) is recommended as an aid in the determination
of tumors of myogenic origin, such as those arising from smooth muscle,
leiomyomas and those derived from striated muscle. The antibody does not
recognize other intermediate filament proteins.
Refer to page 57 for further information about Clone DE-R-11.
Origin Desmin (Clone DE-R-11) on bowel. Paraffin section.
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Estrogen Receptor
Clone 6F11
50 Tests ORG-8871
Antigen Background
IVD IVD
Estrogen receptor (ER) expression in breast cancer tissue is an important
parameter in the prediction and response to endocrine therapy. Monoclonal
antibodies to ER have allowed the determination of ER status to be carried out
in routine histopathology laboratories quantitatively and qualitatively.
Product Specific Information
Origin Estrogen Receptor (Clone 6F11) is indicated as an aid in prognosis and
prediction of therapy in breast cancer, it binds specifically to the ER alpha
antigen in the nuclei of normal and neoplastic tissues.
Refer to page 61 for further information about Clone 6F11.
Origin Estrogen Receptor (Clone 6F11) on breast carcinoma. Paraffin section.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.