QF0159 Marketing Release Record

Primary Antibodies
Novocastra Adenomatous Polyposis
Coli Protein (APC)
Clone EMM43
1 mL lyophilized NCL-APC P
See also APC (Adenomatous Polyposis Coli Protein) on page 23.
Novocastra Adenovirus
Clone 10/5.1.2
1 mL lyophilized NCL-ADENO I
The Adenoviridae are a family of double-stranded DNA viruses. They may
cause a variety of infections involving respiratory, ocular, genito-urinary or
enteric systems. Adenoviruses may cause life-threatening infections in
transplant recipients, AIDS patients and immunocompromised patients.
Product Specific Information
NCL-ADENO is a pan adenovirus specific reagent. Reactivity has been
confirmed with adenovirus serotypes 1 to 7, 40 and 41 as primary isolates in
tissue culture. NCL-ADENO does not cross-react with tissue culture isolates
of respiratory syncytial virus, influenza virus types A and B, parainfluenza
virus types 1, 2, 3 and 4b, herpes simplex virus types 1 and 2, varicella-zoster
virus, cytomegalovirus, mumps virus, measles virus, echovirus 19, coxsac67e
B4 virus, poliovirus types 1, 2 and 3 or negative tissue culture cells used in
routine virus isolation.
Human nasopharyngeal secretion: immunofluorescence for Adenovirus using NCL-ADENO.
Note intense staining of Adenovirus infected respiratory epithelial cells. Acetone-fixed cells.
Novocastra Akt (Phosphorylated)
Clone LP18 Reference Range
1 mL, 0.1 mL liquid NCL-L-Akt-Phos P (HIER) W
Antigen Background
Akt-1, also referred to as Protein Kinase B (PKB) or Rac alpha is a member of
the Akt serin /threonine protein kinase family. It plays an important role in
many biological responses including metabolism, cell survival and growth by
phosphorylation and inactivating several targets including GSK 3 beta,
caspase 9, BAD and the Forkhead transcription factor.
Product Specific Information
NCL-L-Akt-Phos is not recommended for use with PBS, since the use of PBSbased
wash buffers and possibly PBS-based antibody diluents gives
increased background staining and decreased staining intensity. Proprietory
reagents from Leica or TBS-based wash buffer and diluents are
recommended.
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RUO*
For detailed information on all products please visit our website:
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Human skin: immunohistochemical staining for phosphorylated Akt using NCL-L-Akt-Phos.
Note intense nuclear staining. Paraffin section.
Novocastra ALK (Anaplastic Lymphoma
Kinase) (CD246) (p80)
Clone 5A4 Reference Range
1 mL, 0.1 mL lyophilized NCL-ALK P (HIER)
7 mL BOND ready-to-use PA0306 P (HIER)
Antigen Background
Anaplastic large cell lymphoma (ALCL) is usually composed of large
pleomorphic cells which are reported to express CD30 antigen and the
epithelial membrane antigen (EMA). These tumor cells tend to occur in
younger individuals and may be associated with cutaneous and extranodal
involvement. A proportion of these cases contain a chromosomal
translocation t(2;5) (p23; q35). This results in a hybrid gene encoding part of
the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the
anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large
cell lymphomas account for approximately 25 percent of all non-Hodgkin's
lymphomas in children and young adults, of which one third carries the NPM-
ALK gene translocation.
Human anaplastic lymphoma: immunohistochemical staining for anaplastic lymphoma
kinase (p80) using NCL-ALK. Note cytoplasmic staining of large pleomorphic cells. Paraffin
section.
Novocastra Alpha-1-Antichymotrypsin
Polyclonal
1 mL lyophilized NCL-A1ACp ASR
Analyte Specific Reagent. Analytical and performance characteristics are
not established.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.
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