QF0159 Marketing Release Record

Primary Antibodies
Novocastra Myelin Basic Protein
Clone 7H11
1 mL, 0.1 mL lyophilized NCL-MBP P (HIER)
Myelin basic protein is reported to account for about 30 percent of the
proteins in myelin found in the central nervous system. It can induce
experimental allergic encephalomyelitis (EAE), a T-lymphocyte mediated
disease due to delayed-type hypersensitivity; though each animal species
appears to respond to a different fragment of the 170 amino acid
polypeptide. Four different isoforms have been identified through cDNA
cloning. All four of these variants are identical except for the insertion or
deletion of two peptide fragments encoded by exons 2 and 5. Myelin basic
protein is reported to be expressed in oligodendrocytes, myelin of white
matter in the brain and spinal cord and in peripheral nerves, though it is
expressed less abundantly in gray matter.
Product Specific Information
NCL-MBP was raised to guinea pig myelin basic protein and is reactive with
human myelin basic protein.
Human spinal cord, cervical: immunohistochemical staining for myelin basic protein using
NCL-MBP. Note cytoplasmic staining of cells in white matter. Paraffin section.
Novocastra Myeloperoxidase
Clone 59A5
1 mL lyophilized NCL-MYELO P IVD
7 mL BOND ready-to-use PA0491 P (HIER)
Antigen Background
Myeloperoxidase is a lysosomal enzyme found in cells of the myeloid series
which metabolises most of the hydrogen peroxide generated by activated
phagocytes. It is a major constituent of azurophilic cytoplasmic granules that
uses hydrogen peroxide to oxidise a variety of aromatic compounds and
chloride ions to hypochlorous acid (HOCI), a strong oxidant. HOCI is the most
bacteriocidal oxidant known to be produced by neutrophils. HOCI reacts with
proteins to form cytotoxic chloramines. Myeloperoxidase is reported to be a
major component in all myeloid cells, including mature granulocytes and is a
superior marker to myeloperoxidase mRNA, whose level decreases with the
maturation of the cell and is not detectable from the myelocyte stage
onwards. Myeloperoxidase is reported to be expressed in neutrophil
granulocytes and monocytes in blood, in precursors of granulocytes in the
bone marrow and in Kupffer cells of the liver.
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RUO*
IVD
Human bone marrow, granulocytic sarcoma: immunohistochemical staining for
myeloperoxidase using NCL-MYELO. Note intense cytoplasmic staining of malignant myeloid
cells. Paraffin section.
Novocastra Myogenin (Myf-4)
Clone LO26
1 mL lyophilized NCL-Myf-4 P (HIER) W
1 mL liquid NCL-L-Myf-4 P (HIER) W IVD
7 mL BOND ready-to-use PA0226 P (HIER)
Antigen Background
Rhabdomyosarcomas are a class of myoblast-derived soft tissue sarcomas
that usually express a number of muscle-specific genes and primarily affect
children and young adults. Differentiation of myogenic cells is controlled by a
set of regulatory genes including MyoD1, myogenin, Myf-5 and Myf-6. Myf-4
is the human homolog of myogenin. Its gene product, together with that of
Myf-3, accumulates in the nucleus of differentiated cells.
Human rhabdomyosarcoma: immunohistochemical staining for Myf-4 protein using
NCL-L-Myf-4. Note staining of a proportion of tumor cell nuclei. Paraffin section.
Novocastra Myoglobin
Clone MYO18
1 mL, 0.1 mL lyophilized NCL-MYOGLOBIN ASR
7 mL BOND ready-to-use PA0727 P (HIER) IVD
Analyte Specific Reagent. Analytical and performance characteristics are
not established.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.
IVD
IVD