QF0159 Marketing Release Record

Human cerebellum: immunohistochemical staining for synaptic vesicle protein 2 using
NCL-SV2. Note staining of neuronal processes. Paraffin section.
Novocastra Synaptophysin
Clone 27G12
1 mL, 0.1 mL lyophilized NCL-SYNAP-299 F P (HIER) W
1 mL liquid NCL-L-SYNAP-299 F P (HIER) W IVD
7 mL ready-to-use RTU-SYNAP-299 F P (HIER) IVD
7 mL BOND ready-to-use PA0299 P (HIER) IVD
Antigen Background
Synaptophysin is an integral membrane glycoprotein with a molecular weight
of 38 kD. It is reported to occur in presynaptic vesicles of neurons in brain,
spinal cord, retina, in similar vesicles of the adrenal medulla as well as in
neuromuscular junctions. Synaptophysin may be involved in synaptic vesicle
formation and exocytosis. Synaptophysin is reported to be expressed in a
wide spectrum of neuroendocrine tumors including neuro-blastomas,
ganglioneuroblastomas, phaeochromocytomas, chromaffin and nonchromaffin
paragangliomas. Synaptophysin is also reported to be expressed
in neuroendocrine tumors of epithelial type including pituitary adenomas,
islet cell tumors, medullary carcinomas of thyroid, parathyroid adenomas,
carcinoids of the bronchopulmonary and gastrointestinal tracts,
neuroendocrine carcinomas of the bronchopulmonary and gastrointestinal
tract and neuronendocrine carcinomas of the skin.
Breast carcinoma showing neuroendocrine differentiation: immunohistochemical staining for
synaptophysin using NCL-SYNAP-299. Note cytoplasmic staining of tumor cells. Paraffin
section.
Novocastra Synuclein, Alpha
Clone KM51
1 mL lyophilized NCL-L-ASYN P (HIER)
1 mL liquid NCL-L-ASYN P (HIER) RUO*
Refer to page 22 for further information about Alpha-Synuclein.
IVD
IVD
Novocastra Tartrate-Resistant Acid
Phosphatase (TRAP)
Clone 26E5
1 mL lyophilized NCL-TRAP P (HIER) IVD
7 mL BOND ready-to-use PA0093 P (HIER)
Antigen Background
Tartrate-resistant acid phosphatase (TRAP) is a basic, iron-binding protein
with high activity towards phosphoproteins, ATP and 4-nitrophenyl
phosphate. This isoenzyme has been reported through different applications
to be expressed in human alveolar macrophages, osteoclasts, spleen and
liver. Expression of TRAP is reported to be increased in the spleen and
monocytes of individuals with Gaucher's disease, Hodgkin's disease and the
sera of individuals undergoing active bone turnover. Elevated levels are also
reported to be associated with various B cell and T cell leukemias and
lymphomas, decidual cells, syncytiotrophoblasts and some macrophages
distributed throughout maternal and embryonic tissues.
Human osteoclastoma: immunohistochemical staining for tartrate-resistant acid phosphatase
using NCL-TRAP. Note intense cytoplasmic staining of osteoclasts. Paraffin section.
Novocastra Tau
Clone Tau-2
1 mL lyophilized NCL-Tau-2 P (HIER)
The brain tissues from individuals with Alzheimer's disease are
characterized by an abundance of neurofibrillary tangles, neuropil threads
and abnormal neurites in senile plaques. Tangles represent dense accumulations
of ultrastructurally distinct paired helical filaments whose major
component is a microtubule-associated tau protein.
Product Specific Information
IVD
NCL-Tau-2, raised against the bovine tau protein, cross-reacts with the
phosphorylated form of human tau protein.
Human brain, Alzheimer's disease: immunohistochemical staining for tau protein using
NCL-Tau-2. Note intense staining of senile plaques and the surrounding dystrophic
neurites. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
IVD
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Primary Antibodies