QF0159 Marketing Release Record

Human Colonic Carcinoma: immunohistochemical staining for PMS2 using NCL-L-PMS2.
Paraffin section.
Novocastra Motility-Related Protein-1
(CD9)
Clone 72F6
1 mL lyophilized NCL-CD9 F P (HIER)
See also CD9 (Motility-Related Protein-1) on page 34.
Novocastra Muc Glycoprotein
Antibodies
Clone Ma552
1 mL lyophilized muc-1 core glycoprotein
NCL-MUC-1-CORE F P (HIER) RUO*
Clone Ma695
1 mL lyophilized muc-1 glycoprotein
NCL-MUC-1 F P (HIER) IVD
Clone Ccp58
1 mL, 0.1 mL lyophilized muc-2 glycoprotein
NCL-MUC-2 F P (HIER) IVD
Clone CLH2
1 mL, 0.1 mL lyophilized muc-5AC glycoprotein
NCL-MUC-5AC P (HIER) IVD
Clone CLH5
1 mL, 0.1 mL lyophilized muc-6 glycoprotein
NCL-MUC-6 P (HIER) IVD
Antigen Background
RUO*
Mucins are heavily glycosylated proteins which constitute the major
components of mucus covering the surface of epithelial tissues. Nine distinct
epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been
identified. Various immunohistochemical and in situ hybridization studies
have reported that these mucins are differentially expressed in epithelia with
cell-type specificity. The normal gastric mucosa shows cell-type specific
expression of Muc-1, Muc-5AC and Muc-6 glycoproteins. Muc-1 and Muc-
5AC are found in superficial epithelium and Muc-6 glycoprotein in the deep
glands. Muc-1 and Muc-5AC glycoproteins are reported to be expressed in
many epithelia but Muc-6 glycoprotein is mainly expressed in gastric
mucosa. In addition, Muc-2 glycoprotein is not expressed in normal gastric
mucosa. In gastric cancer, alterations in mucin polypeptide expression have
been reported, including the loss of expression of Muc-5AC glycoprotein,
increased mucin heterogeneity, glycosylation changes and the expression of
simple mucin-type carbohydrates.
Normal human stomach: immunohistochemical staining for Muc-6 glycoprotein using NCL-
MUC-6. Note cytoplasmic staining of mucus secreting cells of the deep glands. Paraffin
section.
Novocastra Multiple Myeloma
Oncogene 1 (MUM-1)
Clone EAU32
1 mL, 0.1 mL liquid NCL-L-MUM1 P (HIER)
7 mL BOND ready-to-use PA0129 P (HIER)
Antigen Background
The MUM-1 (multiple myeloma oncogene 1) gene was originally identified
because of it’s involvement in the t(6:14) translocation observed in multiple
myeloma, which causes the juxtaposition of the MUM-1 gene to the Ig heavy
chain locus. MUM-1 is expressed in late plasma cell directed stages of B cell
differentiation and in activated T cells, suggesting that MUM-1 may serve as
a marker for lympho-hemopoetic neoplasms derived from these cells. The
morphologic spectrum of MUM-1 expressing cells has been found to range
from that of a centrocyte to that of a plasmablast/plasma cell. Consequently
the histogenic value of MUM-1 may be to provide a marker to aid in the
identification of the transition from BCL-6 positive (germinal center B cells) to
CD138 positive (immunoblasts and plasma cells). MUM-1 expression occurs
in a wide range of lymphoid neoplasms including a proportion of diffuse B cell
lymphomas but not myeloid or extra-hemopoietic neoplasms. MUM-1 is
consistently expressed in myeloma cells, Reed Sternberg cells in classic
Hodgkin Disease, and activated and neoplastic T cells.
Human diffuse large B cell lymphoma: immunohistochemical staining for multiple myeloma
oncogene 1 (MUM-1) using NCL-L-MUM1. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
IVD
IVD
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Primary Antibodies