QF0159 Marketing Release Record

Primary Antibodies
Novocastra Caveolin-1
Clone 4D6
1 mL liquid NCL-L-Caveolin-1 P (HIER)
Caveolin-1 is a major structural component of caveolae which are vesicular
invaginations present on the plasma membrane of different cell types. It
plays a regulatory role in several signalling pathways and is reported to be
most abundantly expressed in terminally differentiated mesenchymal cells
such as smooth muscle cells, adipocytes and endothelial cells. High levels
are also reported in fibroblasts where a fine granular membranous and
diffuse cytoplasmic staining pattern is described. In pancreatic cancer,
caveolin-1 is reported to be expressed on the cell membrane and cytoplasm
of cancer cells. Further studies have reported that caveolin-1 is likely to act
as a tumor suppressor in some human malignancies such as sarcomas.
Normal human colon: immunohistochemical staining for caveolin-1 using NCL-L-Caveolin-1.
Note cytoplasmic staining of smooth muscle and endothelium. Paraffin section.
Novocastra CCK-8 (Cholecystokinin)
Polyclonal
0.25 mL lyophilized NCL-CCK-8p P (Enzyme)
Cholecystokinin (CCK) was first isolated as a 33 amino acid intestinal peptide
hormone that binds saturably and reversibly to distinct receptors in brain
and pancreatic cell membranes. In both the brain and intestine, CCK exists
in a number of molecular forms of which the C-terminal octapeptide (CCK-8)
represents the most abundant molecular species. CCK, gastrin, secretin and
vasoactive intestinal polypeptide belong to the gastrointestinal hormone
family. CCK functions to stimulate enzyme secretion from the pancreas, gall
bladder contraction, intestinal motility as well as inhibiting gastrin-induced
acid secretion. CCK also serves as a neurotransmitter and modulates the
action of other neurotransmitters eg dopamine, 5-HT, GABA and excitatory
amino acids. CCK is distributed in several regions of the brain including the
cerebral cortex, hippocampus, amygdaloid nuclei and the hypothalamus.
CCK is localized mainly in peripheral nerve fibers in the myenteric and
submucosal ganglia as well as in endocrine cells of the gastrointestinal
tract.
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RUO*
IVD
Novocastra CD1a
Clone MTB1 Reference Range
1 mL, 0.1 mL lyophilized NCL-CD1a-235 F P (HIER)
1 mL liquid NCL-L-CD1a-235 F P (HIER) IVD
7 mL ready-to-use RTU-CD1a-235 F P (HIER) IVD
7 mL BOND ready-to-use PA0235 P (HIER) IVD
Clone JPM30
1 mL, 0.1 mL lyophilized NCL-CD1a-220 F P (HIER)
Antigen Background
CD1a is a protein of 43 to 49 kD expressed on dendritic cells and cortical
thymocytes. CD1a antigen expression has been shown to be useful in
differentiating Langerhans cells, powerful antigen presenting cells present in
skin and epithelia, from interdigitating cells. Immunohistochemical studies for
CD1a antigen have reported a reduction in epidermal Langerhans cells in
graft versus host disease and the participation of CD1a antigen-positive
dendritic cells in atherosclerotic lesion formation and asthmatic
inflammation.
Product Specific Information
Clone MTB1 detects cortical thymocytes, Langerhans cells in epidermis,
interdigitating cells of dermis and interdigitating cells of stratified squamous
epithelium of tonsil. Clone MTB1 may also detect small focal groups of
lymphocytes outside the germinal centers of tonsil indicating a crossreaction
with CD1b antigen. Clone JPM30 detects cortical thymocytes,
Langerhans cells in epidermis, interdigitating cells of dermis, interdigitating
cells of stratified squamous epithelium of tonsil but in addition it stains sweat
gland ducts in the dermis and epithelial cells of small intestine indicative of
cross-reactivity with CD1d antigen.
Normal human skin: immunohistochemical staining for CD1a antigen using NCL-CD1a-235.
Note intense membrane staining of Langerhans cells. Paraffin section.
Novocastra CD2 (LFA-2)
Clone AB75
1 mL, 0.1 mL lyophilized NCL-CD2-271 P (HIER)
1 mL liquid NCL-L-CD2-271 P (HIER) IVD
7 mL ready-to-use RTU-CD2-271 P (HIER) IVD
Clone 11F11
7 mL BOND ready-to-use PA0271 P (HIER)
Antigen Background
The CD2 antigen (LFA-2) is a monomeric 45 to 58 kD glycoprotein. It is an
accessory molecule important in mediating the adhesion of activated T cells
and thymocytes with antigen-presenting cells and target cells.
Products in this catalog are subject to regulatory approval.
Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.
IVD
IVD
IVD
RUO*