QF0159 Marketing Release Record

Novocastra Topoisomerase II Alpha
Clone 3F6
1 mL lyophilized NCL-TOPOIIA F P (HIER) W
Antigen Background
Topoisomerase II alpha is an essential nuclear enzyme involved in DNA
replication and is a target for many anti-cancer drugs used for cancer
therapy. Decreased expression of topoisomerase II alpha is the predominant
mechanism of resistance to several chemotherapeutic agents. A significant
variation in the range of expression of this protein has been reported in many
different tumors. Reports of the analysis of primary breast tumors have
indicated that topoisomerase II beta is more widely expressed than
topoisomerase II alpha. Topoisomerase II alpha expression and activity is
linked to the cell cycle and is associated with the proliferation status of cells.
Human bladder tumor: immunohistochemical staining for topoisomerase II alpha using
NCL-TOPOIIA. Note intense nuclear staining of malignant cells and occasional mitotic
figures. Paraffin section.
Novocastra Toxoplasma gondii P30
Antigen
Clone TP3
1 mL lyophilized NCL-TG P (HIER)
RUO*
Toxoplasma gondii is a ubiquitous protozoan parasite which can infect
healthy humans, often asymptomatically, but may also cause severe
congenital defects in the fetus and life-threatening infection in
immunocompromised hosts. It has been shown that P30, also referred to as
SAG-1, the major surface antigen of Toxoplasma gondii tachyzoites is
involved in the first steps of invasion. This antigen has been reported to have
generated interest as a potential subunit for vaccine production. P30 is a
highly conserved antigen between most strains of Toxoplasma gondii.
Infected human brain: immunohistochemical staining for Toxoplasma gondii P30 antigen using
NCL-TG. Note staining of the parasites in infected areas. Paraffin section.
IVD
Novocastra Transforming Growth Factor
Beta
Clone TGFB17
1 mL, 0.1 mL lyophilized NCL-TGFB P (HIER)
Transforming growth factor beta (TGFB) is a potent cell regulatory
polypeptide homodimer of 25 kD. It variably affects cell growth, differentiation
and other aspects of cellular metabolism such as extracellular matrix
production. Its effect depends upon the cell type and other growth factors
present but in general, TGFB inhibits the growth of epithelial cells and
stimulates the growth of mesenchymal cells. Most breast lesions, benign
and malignant, involve abnormal proliferation and altered architecture of
stromal and/or epithelial elements. Inflammatory cells present in the earliest
lesions of progressive systemic sclerosis (PSS) are reported to release
TGFB possibly resulting in chemotactic recruitment of additional chronic
inflammatory cells. Platelets, a rich source of TGFB, are known to exhibit
aggregability and may contribute to the etiology of PSS.
Human breast carcinoma: immunohistochemical staining for transforming growth factor beta
using NCL-TGFB. Note cytoplasmic staining of tumor cells. Paraffin section.
Novocastra Transforming Growth Factor
Beta Receptor (Type 1)
Clone 8A11
1 mL lyophilized NCL-TGFBR1 P (HIER)
RUO*
RUO*
Transforming growth factor beta (TGFB) is a potent cell regulatory
polypeptide homodimer of 25 kD. It variably affects cell growth, differentiation
and other aspects of cellular metabolism such as extracellular matrix
production. Its effect depends upon the cell type and other growth factors
present but in general, TGFB inhibits the growth of epithelial cells and
stimulates the growth of mesenchymal cells. Most breast lesions, benign
and malignant, involve abnormal proliferation and altered architecture of
stromal and/or epithelial elements. Platelets, a rich source of TGFB, are
known to exhibit aggregability and may contribute to the etiology of PSS.
Human colon, ulcerative colitis: immunohistochemical staining for transforming growth factor
beta receptor (type 1) using NCL-TGFBR1. Note membrane staining of a proportion of epithelial
cells and lymphocytes. Paraffin section.
F Frozen I Immunofluorescence E Electron microscopy
P Paraffin C Flow cytometry O Other applications
W Western blotting
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Primary Antibodies