QF0159 Marketing Release Record

Primary Antibodies
Novocastra Cytokeratin 16
Clone LL025
1 mL lyophilized NCL-CK16 F P (HIER) IVD Cytokeratins 16 and 6
are expressed where keratinocytes are undergoing rapid turnover in the
suprabasal region. Cytokeratins 16 and 6 are reported to be found in various
pathological
carcinomas.
states, including wound healing, psoriasis and certain
Product Specific Information
NCL-CK16 reacts with the human cytokeratin intermediate filament protein
(48 kD) identified as cytokeratin 16.
Novocastra Cytokeratin 17
Clone E3
1 mL lyophilized NCL-CK17 F P (HIER) W
7 mL BOND ready-to-use PA0114 P (HIER)
Antigen Background
In normal tissues cytokeratin 17 is reported to be expressed in basal cells of
complex epithelia eg basal cells of pseudostratified epithelium in the trachea,
larynx, bronchi, myoepithelial cells in salivary glands and sweat glands. In
neoplastic tissue, cytokeratin 17 is reported to be expressed in squamous cell
carcinomas of the lung, cervix and oral cavity.
Product Specific Information
NCL-CK17 reacts with the human cytokeratin intermediate filament protein
(46 kD) identified as cytokeratin 17.
Human squamous cell carcinoma, floor of the mouth: immunohistochemical staining for
cytokeratin 17 using NCL-CK17. Note cytoplasmic staining of malignant cells. Paraffin section.
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Novocastra Cytokeratin 18
Clone DC-10
1 mL lyophilized NCL-CK18 F P (HIER)
Antigen Background
Cytokeratin 18 is normally co-expressed with cytokeratin 8 and is found in
most simple ductal and glandular epithelia.
Product Specific Information
NCL-CK18 reacts with the acidic cytokeratin intermediate filament protein (45
kD) identified as cytokeratin 18. Cytokeratin 18 is reported not to be expressed
in stratified squamous epithelium on most squamous cell carcinomas.
Human colonic adenocarcinoma: immunohistochemical staining for cytokeratin 18 using
NCL-CK18. Note cytoplasmic staining of malignant epithelial cells. Paraffin section.
Novocastra Cytokeratin 19
Clone b170
1 mL lyophilized NCL-CK19 F P (Enzyme) IVD
7 mL BOND ready-to-use PA0799 P (Enzyme)
Antigen Background
The smallest human cytokeratin filament protein (40 kD) has been identified
as cytokeratin 19 and has been reported to be expressed in a large number of
epithelial cell types, including many ductal and glandular epithelia.
Product Specific Information
NCL-CK19 produces a complex heterogenous staining pattern in nonkeratinizing
squamous epithelia and hair follicles, with strong staining of the
basal layer observed.
Human rectal adenocarcinoma: immunohistochemical staining for cytokeratin 19 using
NCL-CK19. Note cytoplasmic staining of malignant epithelial cells. Paraffin section.
IVD
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Please consult your Leica Microsystems representative for availability in your region.
* For Research Use Only. Not for use in diagnostic procedures.
IVD